2016-06-17.log

--- Log opened Fri Jun 17 00:00:32 2016
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kanzureyep....05:30
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eudoxialol kanz you were right about Ethereum being a bloodbath05:33
kanzurebig of you to admit it05:34
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kanzure"I've got #29, and still one account which did not join. Give me your email and I'll send you the keys"05:44
kanzure<3 utter madness out there05:44
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nmz787eudoxia: kanzure: I asked a few days ago if ethereum ws good or bad, and now I see a comment about bloodbath??09:03
kanzurenmz787: ethereum foundation central command has decided to force some changes in the system to rollback $60 million stolen earlier today09:04
kanzurehttps://news.ycombinator.com/item?id=1192190009:04
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nmz787hmm, I kinda feel like that founder guy might have also been at toorcamp09:11
nmz787but I can't tell.09:11
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nmz787wow, i bet that contract programmer is getting hell, from others or themselves :(09:14
nmz787hmm, too bad this doesn't apparently have an IPS screen and backlit keyboard :(09:25
nmz787.title https://www.sparkfun.com/products/1389609:25
yoleauxPi-Top (Green) - KIT-13896 - SparkFun Electronics09:25
nmz787"The pi-top is a DIY laptop you build yourself that helps you start learning how to code, create awesome devices and take your knowledge to the next level. This Raspberry Pi powered laptop is an excellent resource to any budding hobbyist, student or intrigued user wanting to learn more about the capabilities of the credit card-sized development board. The only thing this kit doesn’t include is a speaker and its own Raspberry Pi;"09:26
chris_99it's ridiculously expensive imo09:26
nmz787yep09:28
nmz787i guess it is reasonable since it is likely pretty small volume manufactiruing09:28
nmz787but c'mon, give me a backlit kb09:28
chris_99heh09:28
nmz787aww, this has nothing to do with a bio-mouse: http://hackaday.com/2016/06/17/mouse-brains-plus-line-laser-equals-rangefinder/09:30
kanzure.title http://bbci.de/supplementary/EEGconnectivity/BBCB.html09:35
yoleauxBerlin Brain Connectivity Benchmark (BBCB)09:35
kanzure"The Berlin Brain Connectivity Benchmark (BBCB) is a Matlab based simulation framework for generating electro- and magnetoencephalographic (EEG and MEG) data within a realistic electromagnetic volume conductor (head) model for the purpose of benchmarking EEG/MEG based brain connectivity estimation methodologies. Its development is motivated by our feeling that, while brain connectivity analyses using interaction measures such as Granger ...09:36
kanzure... Causality are frequently applied to EEG/MEG data, their validity to detect brain interactions rather than more trivial properties of the data is rarely validated in suitable simulations. Problems such as spurious connectivity affecting certain interaction measures are overlooked when essential features of real EEG/MEG data such as mixed brain signals or correlated noise are not reflected in a simulation (see e.g. [5-7]). Their impact ...09:36
kanzure... might therefore not be entirely clear to all researchers employing such measures. The goal of BCCB framework is therefore to facilitate the assessment of entire source connectivity estimation pipelines, which may be composed of separate pre-processing, inverse source reconstruction and connectivity estimation steps, as a whole, as opposed to benchmarking each analysis step separately under conditions that may be too simplistic."09:36
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maakuif only there was a way to short ether10:25
xentraceither Ⓑ or ether?10:28
xentracoh, just ether. not either10:28
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juri_nmz787_i: any contact info for that other person in the aluminium levitation business?10:46
nmz787_ijuri_: hrmm, all I know if he was near Yakima WA10:50
nmz787_iand I think he does computer security as consulting trade10:51
nmz787_ihe was very tall10:51
juri_ok, so tall computer consultants in washington.10:52
juri_oddly enough, i might be able to do something with that. thanks. ;)10:53
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nmz787_ihttp://hackaday.com/2015/02/24/retrotechtacular-step-up-and-get-your-transformer-training/11:02
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thegtabotEyy lmao11:08
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gnushahttps://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=133e394d Bryan Bishop: remove some old headers >> http://diyhpl.us/diyhpluswiki/transcripts/coindesk-consensus-2016/why-bitcoin-still-matters/12:57
gnushahttps://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=8bcf8f73 Bryan Bishop: also document molecular lego stuff >> http://diyhpl.us/diyhpluswiki/dna/projects/12:58
nmz787_ihmm, I wonder what the 'defects per million' for childbirth is13:20
nmz787_i(to compare to semiconductor yield)13:21
nmz787_i"Birth defects affect one in every 33 babies (about 3% of all babies) born in the United States each year"   (from http://www.cdc.gov/ncbddd/birthdefects/data.html)    so that'd be 30,000 DPM13:22
nmz787_ihigher than semiconductor mfg targets13:23
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kanzurelooks like we might have to add "sponsored by george church" back into the /topic13:46
nmz787_iwhy?13:47
nmz787_iwhat has he done for us lately?13:47
kanzurethis channel has become appropriated by the human genome project13:47
nmz787_i?13:47
kanzurejust got off a long phone call with them13:47
nmz787_ii thought that is old news13:47
nmz787_ias in like done 10 years ago13:48
nmz787_i( i guess I remember you mentioning something about this recently)13:48
nmz787_i(but don't remember details)13:48
kanzurenmz787: they have decided to make a human genome project focused on human genome synthesis using enzymatic approaches13:48
nmz787_iah13:48
kanzurenmz787: http://science.sciencemag.org/content/early/2016/06/03/science.aaf685013:49
kanzureerr,13:49
kanzurehttp://diyhpl.us/~bryan/papers2/bio/The%20human%20genome%20project%20-%20write,%20hgp-write%20-%202016.pdf13:49
juri_i was reading about that. reminds me a lot of what we were trying to accomplish last summer.13:50
nmz787_iisn't church still sport the boring Gen9 outfit though?13:50
kanzurehe supports many things13:51
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eudoxiahey congrats kanzure14:08
kanzuregeorge says that one of the main problems continues to be assembly even if we do figure out highly parallelized oligo synthesis14:11
kanzureso therefore andrew wants to focus on enzymatic approaches and such14:12
kanzurei would call that the major bottleneck. but there's also lots of software that doesn't entirely exist for these things.14:12
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nmz787_ikanzure: did you ask what those assembly problems were?14:30
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maakuuse dna origami on the tips or between genes to provide work grips14:44
maakubut i'm a newb in biology don't listen to me14:44
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nmz787_i1"A primary consideration- if I can't get 1 page or less ikea style instructions that 90% of the researchers can understand then it is too complicated!"14:48
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drethelinnmz781_i1 even with that lots of people fuck up the protocol14:57
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kanzurenmz787: just the traditional problems.... pick n place of 100 million spots is not quick.15:03
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nmz787_i1kanzure: they're really still talking about macro/meso handling solutions?15:04
nmz787_i1that is both sad and relieving at the same time15:05
kanzurethere aren't other options at the moment.15:05
nmz787_i1right, not when you have $100 million15:05
kanzureenzymatic synthesis might be an option but it's highly theoretical and nobody has any workable ways of doing that15:06
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kanzuremy ribosome manufacturing stuff is cool but it only works for protein synthesis15:06
nmz787_i1i'm talking about not using pick'n'place overall15:06
kanzurewell their only idea for not using pipettes is hacking polymerase but again, that's an unsolved problem15:07
kanzureand my "flooding levels" stuff is sort of boring15:07
kanzureyashgaroth's nicking enzyme assembly stuff might work15:07
nmz787_i1huh, I guess Madoo Varma was right, I have 20 years or so to innovate15:08
nmz787_i1kanzure: so no micro/nano fluidics huh?15:08
kanzuremicrofluidic designs would not be substantially better than pick-and-place15:09
nmz787_i1lol15:09
nmz787_i1sweet15:09
kanzureyes i know you get off on having secrets you don't share...15:09
nmz787_i1yeah I am lonely15:10
kanzurein the microfluidic designs the problem was that even with photolithography you end up with routing problems because high valve count designs don't work yet15:10
kanzureer i mean photolithography for the dna synthesis stage15:10
nmz787_i1sounds like a mfg yield issue15:10
kanzurei doubt it15:11
nmz787_i1oh diff issue then15:11
nmz787_i1still too macro15:11
kanzurepicoliter water droplets were also inappropriate for assembly reactions because you still have the same routing problems getting to the stage where you use picoliter encapsulation before the picoliter drop-drop reaction chamber intersection15:12
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kanzureor was it femtoliter... whatever.15:12
nmz787_i1i was just reading a few days ago neuron cells etch silicon dioxide15:13
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kanzuredid you have a proposal ?15:13
nmz787_i1which is a problem for sensing/neural growth sernsor array chips15:13
nmz787_i1kanzure: I do, discussing some things on Monday with some folks15:14
kanzureyou and your valves..15:17
thegtabotHey guys15:17
nmz787_i1sup thegtabot15:18
thegtabotI'm from hacdc15:19
thegtabotYou guys ever think of establishing a biohacking space for DIY biohackers?15:20
kanzureno, community lab spaces are morally wrong15:20
nmz787_i1thegtabot: lots of them exist already15:20
kanzurecalling them DIY is especially morally wrong15:20
nmz787_i1DIT (do it together)15:20
kanzurejust call it corporate15:20
kanzureor group15:20
nmz787_i1(pronounced DEET, like the famous chemical)15:20
thegtabotAny in Washington d.c?15:21
nmz787_i1thegtabot: https://diybio.org/local/15:22
nmz787_i1thegtabot: https://diyhpl.us/wiki/diybio/groups/15:23
thegtabotFirst I find that there are spaces for computer and electrical engineers to collaborate....15:26
thegtabotNow I know there are biotechnology spaces that are the same way...? I am a very happy man now.15:26
nmz787_i1:)15:28
kanzurezilch content http://neochromosome.com/15:40
kanzurehttp://www.recombinetics.com/ "These animals will possess a wide variety of genetically preferable traits that enhance productivity"15:40
kanzure"develop unique and improved genetic lines of pigs bred to duplicate human diseases such as heart disease, diabetes, and cancer. The result: generations of highly effective drugs and medical devices developed more quickly and at lower costs as Recombinetics models enable testing of both safety and efficacy."15:41
kanzure"using CRISPR and TALENs, the proprietary gene editing technology for which we have global exclusive rights in livestock"15:41
kanzurehttp://www.editasmedicine.com/ http://enevolv.com/ "engineers microorganisms to produce valuable bio-based products from renewable feedstocks"  "enEvolv builds and screens genomic designs in massive parallel – directly in a single culture – on the order of billions of strains per month"15:42
chris_99Random question, say you have paper, with print on, which is then covered with opaque material, can anyone suggest any way to see through opaque material, to see the print on the paper, i've tried IR with a powerful IR beam, but that didn't work alas15:43
kanzurehttp://www.egenesisbio.com/ "mission is to transform xenotransplantation into an everyday, lifesaving ​medical procedure"15:43
nmz787_i1chris_99: I know a guy used a highpower green laser pointer to see through scratch-off plastic covering single-use phone-card codes15:47
drethelinwhy phone-cards and not lottery15:47
nmz787_i1phone cards were a monopoly in his country... i bet lottery is illegal15:47
chris_99nmz787_i1, interesting, and used a standard camera to pick up the result?15:48
nmz787_i1chris_99: I want to say he used his eyes15:48
chris_99heh, that sounds dangerous15:48
nmz787_i1hmm, I wonder if there are MP3/wav to MIDI converters out there.15:51
nmz787_i1I've got a song that is already supposedly '8 bit'... so seems it should convert well15:51
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chris_99i _think_ ages ago, i've seen something that could do that15:51
nmz787_i1it also seems like it would sound pretty good on a tesla coil speaker thing15:52
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nmz787_i1hmm http://www.pluto.dti.ne.jp/~araki/amazingmidi/15:53
nmz787_i1.title15:53
yoleauxWAV to MIDI, wav to mid converter, music transcribe software, freeware, AmazingMIDI15:53
chris_99cool15:53
nmz787_i1hmm, so I am guessing the general technique would be, load audio, do FFT on small chunks at a time, then for each FFT peak, find the closest MIDI note?15:55
chris_99when you press a note on a piano, like A, or whatnot, im assuming it's not a single sine wave though, are there lots of harmonics?15:56
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nmz787_i1hmm, good question16:01
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xentracnmz787: there are a bunch of algorithms for music transcription, but in the polyphonic case, it's still a substantially unsolved problem16:54
xentracI suspect probabilistic programming languages will conquer it shortly16:55
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xentracchris_99: there are a lot of kinds of radiation you can use and a lot of things you can detect about the radiation16:56
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kanzurehmph21:53
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nmz787xentrac: polyphonic meaning multiple frequencies at once?23:06
nmz787.tell chris_99 3d-printer with magnetometer to map magentics http://hackaday.com/2016/06/17/hackaday-prize-entry-visualizing-magnetic-fields/23:11
yoleauxnmz787: I'll pass your message to chris_99.23:11
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--- Log closed Sat Jun 18 00:00:33 2016

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