2016-07-22.log

--- Log opened Fri Jul 22 00:00:03 2016
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CaptHindsighthttp://medicalxpress.com/news/2016-07-chinese-team-human-crispr-trial.html06:55
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kanzurerj0ridkf43328rfh0dsa07:57
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Josh|NH4HHi everyone08:54
kanzuregreetings08:54
Josh|NH4HI've been thinking about skyhooks lately08:55
kanzurehow goes the dyson sphere deployment plans?08:55
Josh|NH4HI've never been much into dyson spheres08:55
Josh|NH4HThey seem a bit like overkill08:55
kanzuredyson swarms?08:55
kanzureanyway do you mean tethers?08:56
Josh|NH4HWell, sort of08:57
Josh|NH4HI'm thinking wheels08:57
Josh|NH4HRotating in orbit so that the bottom has a substantially reduce speed relative to the bulk velocity of the structure as a whole08:57
Josh|NH4H(A spinning wheel is more stable than a spinning tether)08:57
kanzurehttp://tethers.com/Bibliography.html08:57
kanzurehttp://tethers.com/MXTethers.html08:58
kanzurere: rotating and momentum exchange tethers, see https://www.youtube.com/watch?v=mPx1Nq80jm808:58
kanzureprobably around the 2m 45sec mark08:58
Josh|NH4HI've been thinking about them more from a theoretical standpoint than a practical one tbh08:59
Josh|NH4HThink about the space elevator09:00
Josh|NH4HPeople talk about CNTs like they're the be-all, end-all of space elevator technology, but really they're just the beginning09:00
Josh|NH4HAnd as a matter of fact a space elevator is probably more useful as a HVDC power conduit for space-based solar panels than it is for transferring actual cargo09:01
kanzurekeith henson has been spending most of his time on wireless power transmission from solar power satellites09:02
Josh|NH4HWireless power transmission has huge losses though, doesn't it?09:02
Josh|NH4HNot to mention targetting problems09:02
Josh|NH4Hs\targetting\targeting09:03
kanzure"Beamed Energy Bootstrapping" https://www.youtube.com/watch?v=VEkZkINrJaA09:05
Josh|NH4HCan't watch right now09:05
Josh|NH4HI'm at work unfortunately09:05
Josh|NH4HOne of the cool things about what that website called a rotovator but I call a hypersonic skyhook is that you can have 1G settlements located in the skyhook09:06
kanzure17:19 < fenn> so much hype about space elevators, and yet nobody even knows what a rotovator is09:09
Josh|NH4HI would argue a rotovator is just as good as a space elevator if you expect to have as much mass going down as up09:10
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kanzureJosh|NH4H: anyway your argument is that it's probably easier to transmit power than cargo, so different material requirements?09:14
Josh|NH4HNot easier necessarily as 36000 km of wiring will be extraordinarily heavy09:15
Josh|NH4HMore worthwhile09:16
Josh|NH4HThe entire space economy is chump change compared to energy09:16
Josh|NH4HAnd in orbit you can do a lot better in terms of power per square meter than anywhere on Earth09:17
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maakuspace solar power requires getting tons of solar panels into orbit though10:07
maakuany kind of in-space commerce is replicating10:07
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Josh|NH4HAgree the panels should probably be made from in-space materials10:08
Josh|NH4Hotoh if you have a space elevator they might not be so expensive to send up10:09
maakuif you have $MAGIC10:13
xentracJosh|NH4H: I feel like solar power satellites are almost a post-Type-1 thing10:17
xentracthey make sense once they enable you to capture energy you would have lost10:17
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xentracor, potentially, if it becomes easier to fabricate panels on orbit than in the Atacama10:18
Josh|NH4Hxentrac, that's not true per se10:18
xentracmaybe for political reasons, say10:19
Josh|NH4HBeing on a rotating sphere reduces mean insolation by 2pi relative to a panel in empty space10:19
Josh|NH4HIt has the possibility to substantially reduce the money you spend on solar generation equipment10:19
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xentracbut satellites on orbit are also on a rotating sphere10:20
xentracand I think you mean 4, not 2π10:21
xentracin the sense that 4πr²/(πr²) = 410:21
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xentracwhat you actually lose in density by capturing energy from terrestrial heliostats instead of orbital ones is the atmospheric attenuation, which is about 30%10:23
xentracsolar constant above atmosphere ≈1.3kW/m²; down here it's under 110:24
xentracbut self-replicating solar panel factories displacing delicate desert ecosystems are viable a lot sooner than panels in orbit10:27
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maaku#MakeNewMexicoGreatAgain10:37
Josh|NH4HXentrac, no I mean 2pi10:39
Josh|NH4HBecause an object on the surface of the Earth has to rotate with it.  An object in GEO will have a direct line to the sun virtually all the time, and can turn to point directly at it without blocking other panels in the array10:39
Josh|NH4HXentrac, you're right when you're a type 1+ civilization, but right now capital costs matter more than available energy10:42
Josh|NH4HAtmospheric attenuation pushes the factor from ~6.3 to ~810:45
maakuJosh|NH4H: a simple motor rotates the solar panel..10:47
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Josh|NH4Hmaaku, sure, but in an array on Earth with multiple solar panels you're going to get shadowing if you have more than one panel10:52
Josh|NH4HAnd nighttime still exists10:52
Josh|NH4H[lunchtime brb]10:55
FourFireJosh|NH4H, with current technology, that is carbon nanotubes, space elevator is infeasible at present11:25
Aurelius_Work2launch loop!11:44
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chris_99CaptHindsight, you know you mentioned you use industrial robot arms with LinuxCNC, does that handle the inverse-kinematics for you11:49
kanzureit does kinematics11:54
chris_99ah cool11:54
chris_99am i right in thinking the difficulty with robot arms, is that theres so many DoF, meaning a lot of unknown variables, you need to work out, to reach the final X,Y,Z coords11:55
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Josh|NH4Hfourfire, I agree12:12
Josh|NH4HCNT might not even be enough12:12
FourFirelaunch loops are technologically possible right now, yes, but financially improbable within the next decade at least12:13
FourFireI'd be for tiling the desert with low cost solar panels12:13
FourFirefirst12:13
chris_99are solar panels more efficient that using mirrors12:13
FourFireor even nuclear power, in a place where it is politically feasible12:13
kanzurelarge-scale project funding can be found but the pitch has to be pretty good.12:13
chris_99and say salt12:13
FourFirechris_99, or that, whatever12:14
chris_99yeah, i'm just curious which is more efficient12:14
FourFireusing the suns energy to produce electricity in the most cost effctive way12:14
chris_99Japan had an idea to use satalites12:16
chris_99with solar panels iirc12:16
chris_99to beam the power back via microwaves12:16
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FourFireok, nice idea, now how to pay for rocket launches12:16
chris_99heh12:16
gnushahttps://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=3ae19684 Bryan Bishop: more polymerase notes >> http://diyhpl.us/diyhpluswiki/polymerase/notes/12:17
FourFirethey're "only" 70 Million each these days, but that's still way, way more expensive than making a solar power plant in a desert twice the size12:17
chris_99i hope they 'solve' fusion soon12:18
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kanzure12:16 <@Susume2> an antiparallel sheet with helixes on one side is pretty basic12:26
kanzure12:22 <@Susume2> we have a slightly reduced alphabet in the design puzzles, where cys and ala are outlawed, gly and pro can only be in loops, and there is a penalty for some aromatics12:26
kanzuregrr we need libraries of more predictable AAs instead of this stuff.12:31
kanzure"Spherical nucleic acids" http://sites.northwestern.edu/muri/files/2013/04/Spherical-Nucleic-Acids.pdf12:38
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kanzure.wik living polymerization12:58
yoleaux"In polymer chemistry, living polymerization is a form of chain growth polymerization where the ability of a growing polymer chain to terminate has been removed. This can be accomplished in a variety of ways." — https://en.wikipedia.org/wiki/Living_polymerization12:58
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kanzure"DNA rendering of polyhedral meshes at the nanoscale" http://www.hogberglab.net/media/publications/benson2015mc.pdf13:27
kanzureautodesk plugin for dna origami stuff http://vhelix.net/13:29
kanzure(autodesk maya plugin, rather)13:29
kanzureat least something good can come from thingiverse now, since that translates polyhedral models to dna origami staples13:38
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eudoxialotsa people dead in Munich, thankfully eleitl is safe: https://www.reddit.com/user/eleitl13:43
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kanzuredna origami is probably more predictable than protein folding14:16
kanzurealthough i don't entirely understand the limits of dna origami predictability regarding dnazyme functionality14:16
kanzuremaybe if you throw in functional elements then the whole thing breaks down and doesn't assemble14:17
kanzure"Voltage-dependent properties of DNA origami nanopores" http://pubs.acs.org/doi/abs/10.1021/nl404183t14:26
kanzure"We show DNA origami nanopores that respond to high voltages by a change in conformation on glass nanocapillaries. Our DNA origami nanopores are voltage sensitive as two distinct states are found as a function of the applied voltage. We suggest that the origin of these states is a mechanical distortion of the DNA origami. A simple model predicts the voltage dependence of the structural change. We show that our responsive DNA origami ...14:26
kanzure... nanopores can be used to lower the frequency of DNA translocation by 1 order of magnitude."14:27
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kanzure"Reversible ligation of programmed DNA-gold nanoparticle assemblies" http://pubs.acs.org/doi/abs/10.1021/jacs.5b0568314:38
kanzure"We demonstrate a new method to reversibly cross-link DNA-nanoparticle dimers, trimers, and tetramers using light as an external stimulus. A DNA interstrand photo-cross-linking reaction is possible via ligation of a cyano-vinyl carbazole nucleoside with an opposite thymine when irradiated at 365 nm. This reaction results in nanoparticle assemblies that are not susceptible to DNA dehybridization conditions. The chemical bond between the ...14:38
kanzure... two complementary DNA strands can be reversibly broken upon light irradiation at 312 nm. This is the first example of reversible ligation in DNA-nanoparticle assemblies using light and enables new developments in the field of programmed nanoparticle organization."14:38
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kanzure"Single-step rapid assembly of DNA origami nanostructures for addressable nanoscale bioreactors" http://pubs.acs.org/doi/abs/10.1021/ja307669215:17
kanzurethat is a good idea. you can make polyhedral cylindrical chambers that are spatially addressable by dna. each one can be formed with some linkers or something before closing (to capture an enzyme or other structures).15:19
kanzureand if you wanted to capture one of them on to a surface at a specific location, you could use surface-bound dna hybridization techniques.15:19
kanzurewith barcoding that could be useful. and absent barcoding it could still be useful for in vitro compartmentalization things.15:20
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kanzure"Custom-shaped metal nanostructures based on DNA origami silhouettes" http://pubs.rsc.org/is/content/articlehtml/2015/nr/c5nr02300a15:23
kanzure"synthesized and characterized a TSDzyme consisting of a single catalytic DNAzyme, hemin-G, grafted onto a DNA tetrahedral scaffold" from http://pubs.rsc.org/en/content/articlehtml/2016/sc/c5sc03705k15:30
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CaptHindsight... nanopores can be used to lower the frequency of DNA translocation by 1 order of magnitude." I wonder which nanopores they are referring to16:51
CaptHindsightotherwise they should reduce the errors to 016:51
kanzurethey are talking about a dna origami nanopore, made out of dna16:52
CaptHindsightnot a great nanopore for sequencing electrically16:54
kanzureprobably not16:54
CaptHindsightthere was a recent paper on adjusting the conductivity of DNA16:55
CaptHindsightI forget which sequence had the highest conductivity16:55
CaptHindsighthttp://www.nature.com/nchem/journal/vaop/ncurrent/full/nchem.2545.html16:57
CaptHindsighthttp://phys.org/news/2016-06-scientists-tunable-dna-electronics-applications.html16:57
kanzure"Here we show that guanine (G) runs in double-stranded DNA support delocalization over 4–5 guanine bases. The weak interaction between delocalized G blocks on opposite DNA strands is known to support partially coherent long-range charge transport. The molecular-resolution model developed here finds that the coherence among these G blocks follows an even–odd orbital-symmetry rule and predicts that weakening the interaction between G ...16:58
kanzure... blocks exaggerates the resistance oscillations. These findings indicate how sequence can be exploited to change the balance between coherent and incoherent transport. The predictions are tested and confirmed using break-junction experiments. Thus, tailored orbital symmetry and structural fluctuations may be used to produce coherent transport with a length scale of multiple nanometres in soft-matter assemblies, a length scale ...16:58
kanzure... comparable to that of small proteins."16:58
kanzurewell anyway, i think dnazymes would be a good idea for a polymerase at some point, but for now it seems more expedient to modify some amino acids to be photoswitchable17:12
kanzurewell, ribozymes. but there's not as much rna origami.17:12
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doclI'm partial to the idea of an orbital ring system. You'd have geologically stationary platforms held up by mass streams moving at superorbital velocity.17:28
doclRequires precision physics, but no new materials17:28
doclRelatively short tethers would then be used to get mass from earth surface above the atmosphere. From there, it's a matter of orbital burn with no atmospheric dynamics to worry about.17:30
doclIn the end you'd perhaps want something roughly circular, like Tesla's thought experiment. There would be a superorbital mass stream inside and a geo-stationary platform, which you could in principle walk around the earth on. But the minimal starting system could be a couple of satellites throwing pellets at each other.17:34
doclThe pellets could have built in micropropulsion features for course correction purposes. So being able to hit the other satellite's deflection apparatus precisely every time with ballistics isn't necessary. Also, they don't need to go at an extremely high velocity, if they cumulatively outmass the platform satellites by enough they could be going just a few percent above orbital velocity.17:38
doclSo you could start with 2 1-ton platform satellites with some electromagnetic deflection systems, then say 100 tons of pellets. Put them all in a low orbit to begin with, at opposite sides of the earth. Then start feeding the pellets on a superorbital trajectory until the platforms are stationary, and lower a tether from each of them.17:41
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midnightmagicDoes anyone know what "Aetheric Research Ltd" is or was? Something about memetic hazard writeups..?19:17
kanzurethis sounds like something steve would know about19:20
kanzuremidnightmagic: http://web.archive.org/web/*/http://threekindsofcool.net/aetherltd/*19:22
kanzureoh i see. they cite nick bostrom stuff. yeah steve is living with a nick bostrom coauthor.19:22
kanzurehttp://on-memetics.blogspot.com/2013/10/memetic-hazard.html19:23
midnightmagicWho's ..  oh, Steve is the Aetheric Research guy? Is it just rando science fiction stuff or is it grounded in some kind of science?19:28
kanzurei doubt steve is related to any of that19:31
kanzureit's just a person i am recommending to ask19:31
kanzurethere might be some grounding but it's the type that will get you stuck for years out of a sense of paralysis for not harming the world due to unforeseen consequences or something :P19:31
kanzureor because you worry about time traveling consensus AIs that will punish you for previous atrocities they decide you have committed by your lack of appropriate levels of carefulness or something19:32
kanzure(i'm not 100% versed on the eternal punishment in simulated hells thing re: AI, but whatever-- just be careful out there i guess)19:33
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kanzurepolymerase draft is 21941 words and 54 pages, need to cut it down i guess20:28
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kanzureclearly i do not kow how to use pymol http://diyhpl.us/~bryan/papers2/polymerase/polymerase-images/images.html22:09
yashgarothwhat you trying to do22:10
kanzurejust some images22:13
kanzureapparently it will take a screenshot of the wrong window22:13
kanzureand it seems to write the same image twice? why?22:13
yashgarothbecause open source is magic, or it's secretly emulating 3d view, hard to say22:14
kanzureyashgaroth: take a look at the various draft updates and let me know22:31
yashgarothtoo late for that tonight, will plow through tomorrow22:34
kanzurekk22:38
SloanOnLinuxdocl: Tell me more about this suspending satelites in stationary positions22:47
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maakuSloanOnLinux you just transfer momentum by magnetic breaking pellets.23:32
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maakuSee launch loop and other "active" / dynamic support structures23:33
SloanOnLinuxAre these in orbit or being shot up from the surface?23:33
maakuFrom the surface.23:33
maakuThere's a loop of pellets being shot up, breaker in a loop, and falling back down23:34
maaku*braked23:34
SloanOnLinuxHmm23:34
SloanOnLinuxIt would require energy from both ground and satellite23:35
maakuThe ground station is pushing the stream of pellets up with the same force as the weight of the structure, plus air resistance on the pellets23:35
maakuSatellite structure can be passive.23:35
maakuBreaking recovers energy, not spends it.23:36
maakuIt actually powers the satellite.23:36
SloanOnLinuxI was just about to say thhat23:36
SloanOnLinuxMy mistake23:36
maakuProblem is if something breaks.23:37
SloanOnLinuxWhy do you call it braking?23:37
maakuThe launch loop has good failure modes -- it just slowly relaxes and moves back to the surface.23:38
maakuThe satellite in the other hand would fall.23:38
SloanOnLinuxParachute23:38
SloanOnLinux?23:38
maaku.wik magnetic braking23:38
yoleaux"Magnetic braking is a theory explaining the loss of stellar angular momentum due to material getting captured by the stellar magnetic field and thrown out at great distance from the surface of the star. It plays an important role in the evolution of binary star systems." — https://en.wikipedia.org/wiki/Magnetic_braking23:39
maakuHuh I would have thought that to be a engineering page, not astrophysical23:39
SloanOnLinuxI hope that thrusters get smaller, just like computers have, through technological advancements23:41
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--- Log closed Sat Jul 23 00:00:04 2016

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