| --- Log opened Mon Jul 25 00:00:06 2016 | ||
| maaku | kanzure: had to. there's no way pokemon go doubled nintendo's real value | 00:01 |
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| JayDugger | I don't know, maaku. Pokémon Go demonstrated a new model of gaming possible for Nintendo that doesn't involve manufacturing or consoles. | 06:20 |
| JayDugger | They have still more markets in which to release the game, and they have other IP they can release as AR games. | 06:21 |
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| archels | https://www.jwz.org/blog/2015/06/from-the-gnome-user-interface-guidelines/ | 06:55 |
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| kanzure | fenn: nectome is in oakland | 08:07 |
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| CaptHindsight | "can you come to our location and setup a demo sequencer?" | 10:34 |
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| CaptHindsight | sure if you pay full price and wait 3-6 months for delivery | 10:34 |
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| nmz787_i | sup | 10:39 |
| kanzure | nmz787_i: lotta additions to the doc, plz read. | 10:40 |
| nmz787_i | motorcycling on gravel yesterday was exhilarating... adrenaline was pretty close if not on full-blast | 10:41 |
| nmz787_i | if I open the doc on my work laptop, I think that means the company owns it | 10:41 |
| nmz787_i | maybe not | 10:41 |
| chris_99 | i've heard something like that, if you work on something in company time | 10:42 |
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| nmz787_i | its def part of TV show plots | 10:43 |
| chris_99 | yeah i think i heard it on Silicon Valley heh | 10:43 |
| nmz787_i | yeah | 10:44 |
| nmz787_i | I wonder if there is a way to make that work to our advantage | 10:44 |
| nmz787_i | like use some kind on infectious license or something | 10:44 |
| nmz787_i | in the sense that it has to stay open/public but also has a well-known big corporate name attached | 10:45 |
| nmz787_i | i.e. for google hits and credibility or something | 10:45 |
| chris_99 | haha, interesting idea | 10:46 |
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| kanzure | credibility is already solved, wont be an issue | 10:50 |
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| nmz787_i | kanzure: I was speaking more generally | 10:55 |
| nmz787_i | but I guess I shouldn't open that until later | 10:56 |
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| kanzure | "Greg Fahy's successful self-experimentation has fast-tracked therapy to regrow the thymus and other organs ... His work is now is the basis of the FDA-approved TRIIM trial." | 11:06 |
| kanzure | didn't know that. | 11:06 |
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| Aurelius_Work2 | kanzure : what's that from? | 11:50 |
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| kanzure | grg | 12:07 |
| kanzure | whois luke perrish | 12:09 |
| kanzure | oh nevermind | 12:09 |
| kanzure | i should know that | 12:09 |
| eudoxia_ | Oregon cryo person | 12:15 |
| eudoxia_ | he follows me on twitter | 12:15 |
| kanzure | nah my question was super embarrassing (it's docl) | 12:15 |
| eudoxia_ | yep | 12:15 |
| kanzure | eudoxia_: see PM | 12:16 |
| eudoxia_ | ok | 12:16 |
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| docl | well, there goes my anonymity :P | 12:33 |
| kanzure | your github account has your name | 12:33 |
| docl | ah, good point | 12:34 |
| kanzure | just to be safe, you should change your name and burn down the entirety of oregon | 12:34 |
| docl | sounds like a plan :P | 12:35 |
| fenn | basically no information about their therapy: http://interveneimmune.com/?page_id=1131 http://interveneimmune.com/?ignition_product=the-triim-trial | 12:57 |
| kanzure | if you mean fahy stuff, then maybe a patent search would be better | 12:58 |
| kanzure | heh there is a ukrainian translation of drexler's nanosystems book http://softdroid.net/toc | 13:03 |
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| chris_99 | https://github.com/jisaacso/DeepHeart | 13:08 |
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| kanzure | hm colwiz's parsers are all broken in lots of ways. they get dates wrong.. | 13:35 |
| kanzure | http://engineeringbiologycenter.org/wp-content/uploads/2016/06/HGP-write-Fact-Sheet.pdf | 13:42 |
| kanzure | http://hgpwrite.org/ (seems to be a redirect to http://engineeringbiologycenter.org/ for now) | 13:43 |
| kanzure | http://engineeringbiologycenter.org/faq/ | 13:45 |
| kanzure | "Genomically encoded analog memory with precise in vivo DNA writing in living cell populations" http://science.sciencemag.org/content/346/6211/1256272.short | 13:47 |
| kanzure | this technique seems to use recombinases to record things | 13:48 |
| docl | https://beacon-center.org/blog/2016/05/27/evolving-antimutator-microbial-machines/ | 13:49 |
| docl | Engineered microbes contain heterologous synthetic devices that utilize a heavy proportion of a cell’s resources for expression. These devices cause cellular stress and decrease fitness, resulting in a strong selection for mutations that eliminate expression of any synthetic part that comprises the device. Over time, random mutations that naturally occur in a living host organism will accumulate and | 13:49 |
| docl | render a synthetic device inactive. Microbes are limited by their inherent unpredictability. This poses a challenging problem for engineers. | 13:49 |
| kanzure | "Genetic encoding of DNA nanostructures and their self-assembly in living bacteria" http://www.nature.com/ncomms/2016/160419/ncomms11179/full/ncomms11179.html | 13:50 |
| kanzure | hm | 13:50 |
| kanzure | beacon-center.org does many good things | 13:51 |
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| kanzure | i thought the usual solution for that problem was something like, "make the synthetic device metabolically relevant to the host organism's survival" | 13:53 |
| kanzure | and terminator genes that execute in its absence. i suppose you could argue that it will eventually be removed anyway... but meh. | 13:53 |
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| kanzure | andrew back has been refurbishing a scanning electron microscope http://abopen.com/blog/scanning-electron-microscope-fun/ | 14:08 |
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| kanzure | typetypetype | 14:59 |
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| nmz787_i | who is andrew back? | 15:17 |
| kanzure | uh just someone in the UK doing open hardware things | 15:18 |
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| kanzure | HEx1: still alive? | 15:36 |
| pasky | any tips re getting hold of | 15:42 |
| pasky | > Experimentation with Human Beings: The Authority of the Investigator, | 15:42 |
| pasky | > Subject, Professions, and State in the Human Experimentation Process, Jay | 15:42 |
| pasky | > Katz, ISBN 1610448340, 9781610448345, 1972 | 15:42 |
| pasky | ? | 15:42 |
| nmz787_i | is there a country that excludes people based on intelligence? | 15:44 |
| eudoxia_ | nmz787_i, you mean, turns you away at the airport because of an intelligence agency request? | 15:45 |
| nmz787_i | no, as in you need to be smart to be let in | 15:45 |
| nmz787_i | i.e. IQ test is your visa test | 15:45 |
| nmz787_i | if this doesn't exist, would it be a good idea? | 15:46 |
| eudoxia_ | hahaha I misread that, not that I know of, but I don't think Singapore does it, and if they don't do it noone else does | 15:46 |
| CaptHindsight | visa test?! They check your credit cards now? | 15:48 |
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| nmz787_i | CaptHindsight: http://www.etymonline.com/index.php?term=visa | 15:49 |
| TMA | nmz787_i: USA (for the non-lottery residence/work-permit visas, the person needs to be qualified) | 15:53 |
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| nmz787_i | TMA: we allow people to be grandfathered in though, so this place isn't starting off fresh | 15:53 |
| TMA | nmz787_i: the only place starting off fresh at the moment is Liberland | 15:55 |
| TMA | nmz787_i: i do not know their policy though | 15:55 |
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| TMA | nmz787_i: the problem is no state or supranational organization acknowledges its existence | 15:58 |
| HEx1 | kanzure: yep | 16:24 |
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| HEx1 | kanzure: reading the recent enzymaticsynthesis posts is still on my to-do queue :( | 16:25 |
| kanzure | HEx1: we are drafting a review of the concept | 16:42 |
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| CaptHindsight | DNA barcode printer in action https://ibin.co/w800/2aq0JWfJZfXK.jpg | 19:14 |
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| kanzure | hm. | 20:28 |
| kanzure | "It turns out the brain uses DNA base excision & repair to adjust neurotransmitter levels. This means it inevitably degrades the neural DNA over time. This may be the hardest cause of aging to stop--unless we just turn the mechanism off." | 20:28 |
| kanzure | "Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446239/ | 20:29 |
| fenn | is tet3 important? | 20:37 |
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| Aurelius_Home | anyone know of startups that hire based on projects with little to no 'phone technical interview'? | 21:39 |
| kanzure | blockstream, probably :P | 21:52 |
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| nmz787 | tet3 sounds like something to do with tetracycline | 22:01 |
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| nmz787 | kanzure: "The DNA content of the ocean is doubling every single day." well, it is probably degrading by half too, no? | 22:20 |
| nmz787 | I guess that doesn't matter though | 22:22 |
| nmz787 | so that person on DIYbio mentioned tdt low efficiency, but didn't cite anything for me to follow up on and I couldn't understand where he got his magic numbers... and another guy I talked to last week mentioned synchem being higher efficiency than enzymes (I have to go on that guy being of elder age) and that synChem also prevents deletion operations from being extended further (still haven't re-checked the chem on that... but I feel like ... | 22:43 |
| nmz787 | ... it is more complex chem that introduces some other issues) | 22:43 |
| nmz787 | like an extra capping step or something, that you also have to pull off everytime, but then it like screws up the side-chain information if the chem is too strong | 22:45 |
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| nmz787 | kanzure: have you find a purchasing source for fluorescent reversible terminators? | 23:12 |
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| nmz787 | FWIW google shopping has lamps or something for those search terms | 23:12 |
| nmz787 | hmm, maybe these folks will respond: http://lasergen.com/technology/lightning-terminators/ | 23:16 |
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| nmz787 | 'contact azco biotech' http://seqanswers.com/forums/showthread.php?t=31555#post109424 | 23:56 |
| nmz787 | .title | 23:56 |
| yoleaux | where to purchase reversible terminators - SEQanswers | 23:56 |
| --- Log closed Tue Jul 26 00:00:07 2016 | ||
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