2016-09-11.log

--- Log opened Sun Sep 11 00:00:51 2016
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kanzureoh it's probably because targeting memory consolidation pathways/neurons is difficult with viruses03:40
kanzureor er, with stereotaxic stuff. because poking through lots of brain matter, and such. (viral targeting is probably more possible, to be fair)03:41
fennneither of those are good reasons03:44
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kanzurewhy would that not be a good reason?03:55
kanzurethey probably break all the other brain parts if they try to inject neurons near those targets03:55
kanzurehttp://www.academia.edu/download/39731675/Upgrading_the_sleeping_brain_with_target20151105-18157-51ku9k.pdf03:55
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kanzuremirror tracing task and dream recall http://onlinelibrary.wiley.com/doi/10.1111/jsr.12286/full04:05
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abetuskpsa: pstoedit is an excellent tool.  Worth looking into if you want to convert between formats.  It even goes from postscript to gcode06:00
JayDuggerThank you for posting the link to the HSAM paper, kanzure.06:09
JayDuggerAnd I'll guess "no," but would be interested in knowing whether the head-mounted refrigerator works.06:10
JayDuggerNot super-impressed that the HSAM paper relies so much on "can you keep a mental perpetual calendar," though.06:12
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abetusk.title http://ocw.mit.edu/courses/electrical-engineering-and-computer-science/6-s079-nanomaker-spring-2013/videos/07:25
yoleauxVideos | Nanomaker | Electrical Engineering and Computer Science | MIT OpenCourseWare07:25
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justanotheruser.title https://youtu.be/plVk4NVIUh809:38
yoleauxThe Evolution of Bacteria on a “Mega-Plate” Petri Dish - YouTube09:38
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justanotheruserIs this a common technique? If so, what other evolutionary experiments have been done09:43
CaptHindsightthe problem is sourcing the 4ft square petri dishes09:48
kanzurejustanotheruser: surely you know about the 20 year 40,000 generation ecoli experiments?09:50
justanotheruserI do not09:51
kanzurejustanotheruser: https://en.wikipedia.org/wiki/E._coli_long-term_evolution_experiment09:51
justanotheruserby this technique I mean specifically the large petri dish09:51
CaptHindsightChipotle has been open for 20 years?09:51
justanotheruserbut that is in my interest too09:51
kanzureso that link is a good place to start09:52
kanzurebut also things like https://en.wikipedia.org/wiki/In_vitro_compartmentalization09:52
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justanotheruserWould be interesting if they had a database mapping DNAs to the attributes o fthe growth medium it has survived10:06
kanzurejustanotheruser: http://diyhpl.us/wiki/transcripts/montclare-protein-engineering/directed-evolution/10:25
justanotheruservery interesting10:36
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paskyjustanotheruser: there is also a similar experiment with fruit flies11:53
kanzureand dogs, foxes, tomato, lots of stuff.11:59
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kanzureprobably there's a thing that selects events for memory consolidation. that's probably an ideal target for enhancement. consolidation probably works well enough, and maybe it's the set of things that need to get consolidated that is too fuzzy.12:41
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justanotheruserkanzure: where do I go when sci-hub.la is down13:10
kanzureto the motherland https://vk.com/sci_hub13:10
justanotheruserhow does this even work13:11
justanotheruserI don't speak russian13:11
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kanzureover-annunciate your v's and you'll be fine13:12
justanotherusersrsly though, is there supposed to be a mirror link here or something13:12
kanzurehttp://sci-hub.cc/13:12
justanotheruserdanke13:13
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kanzure"A cognitive prosthesis for memory facilitation by closed-loop functional ensemble stimulation of hippocampal neurons in primate brain" http://www.sciencedirect.com/science/article/pii/S001448861630149213:56
kanzureoh it is berger. that is okay with me.13:57
kanzurehttp://diyhpl.us/~bryan/papers2/neuro/memory/A%20cognitive%20prosthesis%20for%20memory%20facilitation%20by%20closed-loop%20functional%20ensemble%20stimulation%20of%20hippocampal%20neurons%20in%20primate%20brain%20-%20Berger%20-%202016.pdf13:58
kanzurepage 29 (marked 28) has a diagram of their circuit. those wires sure do seem to go through a lot of important brain matter....14:00
kanzure"Morphometric and histologic substrates of cingulate integrity in elders with exceptional memory capacity" http://diyhpl.us/~bryan/papers2/neuro/memory/Morphometric%20and%20histologic%20substrates%20of%20cingulate%20integrity%20in%20elders%20with%20exceptional%20memory%20capacity%20-%202015.pdf14:03
kanzure"These findings suggest that reduced vulnerability to the age-related emergence of Alzheimer pathology and higher von Economo neuron density in anterior cingulate cortex may represent biological correlates of high memory capacity in advanced old age."14:03
kanzure"Sparse generalized volterra model of human hippocampal spike train transformation for memory prostheses"14:06
kanzure"Nonlinear dynamical modeling of human hippocampal CA3-CA1 functional connectivity for memory prostheses"14:06
kanzure"Neurons and networks organizing and sequencing memories" https://www.researchgate.net/profile/Dong_Song2/publication/270288519_Neurons_and_Networks_Organizing_and_Sequencing_Memories/links/551d805d0cf213ef063e6149.pdf14:08
kanzure"Distributed encoding of spatial and object categories in primate hippocampal microcircuits" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594006/14:10
kanzure"A million-plus neuron model of the hippocampal dentate gyrus: Dependency of spatio-temporal network dynamics on topography" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878386/14:12
kanzure"Hamani et al. (2008) describe a case where a patient was implanted with a deep brain stimulation (DBS) device targeted at the hypothalamus to treat morbid obesity. Through post-operative CT scans, the researchers estimated that the electrodes were located in the hypothalamus, but two were notably proximal to the fornix. Initial stimulation of one electrode evoked an autobiographical memory from decades prior. Of particular relevance, ...14:20
kanzure... the patient developed enhanced memory function. Hamani et al. found that DBS led to greater activation in the patient's hippocampus and parahippocampal gyrus. Suthana et al. (2012) implanted DBS electrodes in the entorhinal cortex of epilepsy patients and found enhanced spatial memory. "14:20
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kanzure"bored george church" https://twitter.com/BoredSynBio21:10
kanzure.tw https://twitter.com/BoredSynBio/status/67333819084612812821:11
yoleauxGarden DNA sequencers that survey soil microbes and are disguised as George Church garden gnomes. (@BoredSynBio)21:11
kanzure.tw https://twitter.com/BoredSynBio/status/62096665254551142421:13
yoleauxA human appendix engineered to do something, anything. (@BoredSynBio)21:14
kanzure.tw https://twitter.com/BoredSynBio/status/61738970322716262521:14
yoleauxFungal spores that are sprinkled onto your yard and grow into a Slip n Slide. #GeorgeDoesThe4th (@BoredSynBio)21:14
kanzure.tw https://twitter.com/BoredSynBio/status/61665487102298931221:14
yoleauxMandatory microbiome tests for presidential candidates to quantify how full of shit they are, and what kind. (@BoredSynBio)21:14
kanzure.tw https://twitter.com/BoredSynBio/status/61628783882548428821:14
yoleauxWorms that don't succumb to the early bird. (@BoredSynBio)21:14
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kanzure.tw https://twitter.com/BoredSynBio/status/60938486764669747221:15
yoleauxGene circuit to selectively regulate dihydrotestosterone stimulation of hair follicles so that my beard is always the perfect length. (@BoredSynBio)21:15
kanzure.tw https://twitter.com/BoredSynBio/status/60919606444549734421:16
yoleauxZoo full of synthetic (and de-extincted) animals, including mammoths and dinosaurs. All profits go to next-gen conservation efforts. (@BoredSynBio)21:16
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