| --- Log opened Sat Sep 17 00:00:55 2016 | ||
| --- Day changed Sat Sep 17 2016 | ||
| JayDugger | I have no good suggestions for making one million USD in two years that don't require you to have almost as much at the start of the two years. | 00:00 |
|---|---|---|
| gradstudentbot | I think using the laser is making me sterile. | 00:01 |
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| ProfSechs | Jaydugger, please suggest. | 00:29 |
| ProfSechs | i'd dedicate myself to it if you're not joking and the ideas are valid. | 00:29 |
| ProfSechs | oh missed the "no" part of "no good suggestions" | 00:33 |
| ProfSechs | late night. | 00:33 |
| JayDugger | Understandable. I rarely clearly read or write until after a few cups of coffee. | 00:36 |
| ProfSechs | Does Ruby and microcontrollers work together or must it be in C or Python? | 00:38 |
| ProfSechs | but for the sake of the argument, does anyone have suggestions on making 1 million? | 00:44 |
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| ProfSechs | I've found out... never you mind. | 00:55 |
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| anoncicada | fenn: not much, no | 01:12 |
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| TMA | ProfSechs: the conventional suggestion to making 1 million dollars is: "Make 10 million dollars. Give 9 million dollars to charity." | 05:35 |
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| kanzure | hmph. | 06:02 |
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| docl | Wouldn't the standard advice be to find a niche market that isn't efficiently served by the current market? | 07:54 |
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| kanzure | well i should have told him wrong channel, really.... | 08:30 |
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| kanzure | .title https://www.youtube.com/watch?v=yUKnOHiDuak | 08:53 |
| yoleaux | How a Group of Elite Scientists Pursued Space Colonies, Nanotechnologies, and a Limitless Future - YouTube | 08:53 |
| kanzure | .title https://www.youtube.com/watch?v=tKVtWg4bJO8 | 08:57 |
| yoleaux | Computational Thinking for a Modern Kidney Exchange - YouTube | 08:58 |
| kanzure | .title https://www.youtube.com/watch?v=F3HboZ2HArw | 09:00 |
| yoleaux | Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves - YouTube | 09:00 |
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| kanzure | kent kemmish sent in some emails: | 11:32 |
| kanzure | https://groups.google.com/forum/#!topic/enzymaticsynthesis/uSXByOsPMSU | 11:32 |
| kanzure | https://groups.google.com/forum/#!topic/enzymaticsynthesis/8Upr8bPY-7I | 11:32 |
| kanzure | https://groups.google.com/forum/#!topic/enzymaticsynthesis/Bx_BEvNfjmU | 11:32 |
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| maaku | JayDugger I have many suggestions for making $1MM in 2 years, but I don't want to end up on any lists by mentioning them. | 12:38 |
| gradstudentbot | Yeah, it's the new grad student's fault. | 12:39 |
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| kanzure | had a long phone call with kent | 13:18 |
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| kanzure | someone was doing in vitro selection directed evolution against ice by dunking into ice or cold water or something, and then sequencing all the proteins that were attached. and then iterating on this a bunch of times to get good anti-ice protein properties. | 13:22 |
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| kanzure | there is a resut in the directed evolution literature that says that if you sequence immediately after your first round of selection, you will already have the variant that will show up in round 20 of selection | 13:51 |
| kanzure | and also various variations of in vitro selection techniques where you sequence after each round and do optimizations that way - or just let each round proceed on its own ---- or continuous selection where you take out some smaples and amplify whatever you like while the rounds are still going (as long as your system doesn't stall itself out of course.....) | 13:52 |
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| kanzure | "System architectures for space missions using molecular nanotechnology" http://www.islandone.org/MMSG/McKendreeThesis95/PhdRsrchProp.html | 14:47 |
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| kanzure | docl: btw you were't around back when paul was writing endless emails to us, so you might have missed some of these: http://www.pdfernhout.net/ | 15:30 |
| kanzure | hrm his 180 page job application to wordpress. hrm. | 15:36 |
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| kanzure | hm. | 16:03 |
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| fenn | wondering about using enzymes to reverse aldehyde fixation | 16:35 |
| fenn | maybe it would be easier to cleave if you used a fixative designed to be cleaved off with enzymes | 16:39 |
| fenn | instead of a tiny molecule | 16:39 |
| fenn | "Give me a trillion bodies on chips. I'll solve death." | 16:46 |
| fenn | kent ranting about bodies on chips https://www.facebook.com/kent.kemmish/posts/10101875737533842 | 16:51 |
| kanzure | "We will build a series of massive largely automated research facilities in which we will guide the evolution of molecular constructs delivered to autologously derived organ systems on chips." | 16:51 |
| kanzure | "We will design our monolithic industrial facilities for a total capacity of trillions of individually addressable and manipulable organ systems, theoretically enabling throughput levels at which every human being on earth would be biomedically represented by hundreds of autologously derived organ systems each grown under different experimental conditions and subjected to continuous massively high-throughput pharmacological engineering ... | 16:52 |
| kanzure | ... guided by comprehensive molecular, cellular, and physiological characterization." | 16:52 |
| kanzure | alright well this is trivial. wire that up to in vitro selection stuff and problem solved. however, i think that this is missing out on gene therapy and "well the program is clearly buggy, so just fix the program itself instead of changing usability" | 16:53 |
| kanzure | like if your system is so broken that you need large-scale mouse programs to evolve cryonics-compatible organisms, and you need large-scale in vitro selection projects wired up to billions of organoids and tissue cultures, then *maybe* you should recommend migrating away from biology in general, rather than trying to fix all the brokenness | 16:54 |
| fenn | i dont get how they're going to approximate an immune system on a chip | 16:56 |
| gradstudentbot | I am sponsored by George Whitesides. | 16:56 |
| fenn | oh, well in that case... | 16:57 |
| kanzure | aren't there only a few hundred archetypes (plus lots of variation for individual acquired immunity things) | 16:57 |
| fenn | yeah the problem is the huge amount of acquired variation that causes auto immune diseases | 16:57 |
| fenn | millions of different clonal populations of b-cells | 16:58 |
| kanzure | also, instead of approximating everyone else's immune system, what about just coercing everyone into an immune system monoculture. and then only focus on those people. | 16:58 |
| fenn | that's a recipe for extinction | 16:58 |
| kanzure | that's only because we suck at building immunity so far other than sheer randomness | 16:59 |
| kanzure | and population size | 16:59 |
| kanzure | and diversity | 16:59 |
| fenn | diversity is anti-fragility | 16:59 |
| kanzure | no screw that, if one person can be immune to something, so can the rest of 'em | 16:59 |
| fenn | they have to dump gigatons of pesticide on monoculture crops just so they don't die | 16:59 |
| fenn | and bananas are constantly in mortal peril | 17:00 |
| fenn | (a clonal population) | 17:00 |
| kanzure | it's much faster to run toxins against immunological screening in a centralized manner, and then distirbute immune system upgrades to your population (which seems to be more feasible when they have the same immune system types) | 17:00 |
| fenn | sure i'm all for downloadable immunity | 17:01 |
| kanzure | you should centralize all the diversity instead of pushing it to the edges | 17:01 |
| kanzure | and i think we could do centralized mutagenesis and construction of novel immunities at a much larger scale than VDJ with TdT in humans. TdT suuucks. it's useful but it sucks and i think we can do better. | 17:02 |
| kanzure | those crop monocultures probably suck because they aren't doing downloadable anything with those crops. just spray-n-pray. | 17:03 |
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| kanzure | there are non-small-molecule fixatives that function like aldehyde? | 17:05 |
| fenn | i don't know | 17:05 |
| fenn | i'd guess that any dialdehyde would work | 17:06 |
| kanzure | who is our taxidermy person? | 17:06 |
| fenn | glutaraldehyde is used for tissue fixation, but it's not that much bigger really | 17:06 |
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| kanzure | what how did meetlog.yaml.txt.git not have "phage display" in any previous conversation? | 18:43 |
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| kanzure | "Subpoena denied: Harvard’s George Church won’t have to testify in CRISPR patent dispute" https://www.statnews.com/2016/09/16/crispr-patent-george-church-subpoena/ | 18:49 |
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| fenn | he probably will anyway | 18:58 |
| fenn | "protein transistor" | 19:02 |
| fenn | is that for real | 19:02 |
| kanzure | from the retracted dna polymerase for dna sequencing paper? | 19:03 |
| fenn | by yu shiun chen? | 19:03 |
| fenn | there's a patent too | 19:03 |
| kanzure | https://ir.nctu.edu.tw/bitstream/11536/22351/1/000319979400018.pdf | 19:03 |
| kanzure | patent is from pacbio | 19:03 |
| kanzure | the chen paper was retracted because the performance is impossible (50 kb reads better than last gen dna sequencing?) | 19:04 |
| kanzure | (superconductance?) | 19:04 |
| fenn | they really should have a huge "RETRACTED" stamp over the entire article. it's not very obvious that it has been retracted | 19:04 |
| kanzure | still, it's an interesting concept even if it was retracted | 19:05 |
| fenn | yes | 19:05 |
| kanzure | also, since pacbio wanted to do something similar, it seems less likely to be completely shit | 19:05 |
| fenn | during my conspiracy theory days i read various papers about DNA being superconducting | 19:05 |
| kanzure | https://www.google.com/patents/US20150065353 | 19:05 |
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| fenn | did i mention i hate patents | 19:07 |
| fenn | .title http://google.com/patents/US8697469 | 19:09 |
| yoleaux | Patent US8697469 - Protein transistor device - Google Patents | 19:09 |
| fenn | seems like it could work | 19:10 |
| kanzure | if you had read the draft you would have seen this in there :P | 19:11 |
| fenn | who is CodeWarrior? (DIYbio) | 19:23 |
| fenn | in UK apparently | 19:28 |
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| kanzure | fenn: it's "peter graham clark" http://diyhpl.us/~bryan/papers2/DNA/A%20hypothetical%20protocol%20for%20DIYBIO%20DNA%20synthesis.pdf | 19:46 |
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| JayDugger | maaku, the "make much money fast" problem has many high-risk solutions. | 19:56 |
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| kanzure | 51fec4dbf6bc823f5c258ca93b961a9ab9fc83d7 269d72f8eefcac04b7668cb110231c5fe344f25d fa2f4aab5deca1d6ca2e62950a8205f7411fe162 08f24121e12cd6a0a6c07be6bf2236abe545b79a | 21:01 |
| gradstudentbot | Holy crap, I need to add that to my slide collection. | 21:04 |
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| kanzure | :facepalm: | 21:09 |
| wrldpcmbl | 1M in 2 years? Order flow, options trading. | 21:46 |
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| gradstudentbot | Yeah, I don't know. | 21:49 |
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| --- Log closed Sun Sep 18 00:00:57 2016 | ||
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