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gnusha | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=e3007947 Bryan Bishop: resistance to sleep deprivation >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ | 07:20 |
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gnusha | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f1e3e495 Bryan Bishop: add more links to mimblewimble transcript >> http://diyhpl.us/diyhpluswiki/transcripts/sf-bitcoin-meetup/2016-11-21-mimblewimble/ | 07:20 |
gnusha | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=2d79938c Bryan Bishop: also describe how to spend small utxos in bitcoin >> http://diyhpl.us/diyhpluswiki/bitcoin/somewhat-open-problems-draft/ | 07:20 |
kanzure | "N-acetylcysteine inhibits muscle fatigue in humans" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC330079/pdf/jcinvest00490-0298.pdf | 07:44 |
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kanzure | .wik delta sleep-inducing peptide | 08:05 |
yoleaux | "Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities." -- https://en.wikipedia.org/wiki/Delta_sleep-inducing_peptide | 08:05 |
kanzure | 'humoral transmission of sleep' http://link.springer.com/article/10.1007/BF00583718 (doesn't seem to work that well?) | 08:06 |
kanzure | "Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia" http://www.pnas.org/content/113/45/12826.short | 08:25 |
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kanzure | 'whole cortex electrophysiology' | 11:00 |
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kanzure | https://en.wikipedia.org/wiki/Hamster_zona-free_ovum_test | 12:00 |
justan0theruser | cool, now I need some hamsters | 12:09 |
kanzure | not if you're fertile | 12:11 |
kanzure | "well i have good news nad i have bad news..." | 12:21 |
JayDugger | Good news, you're fertile. Bad news, the hamster is suing. | 12:46 |
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kanzure | such is life | 12:56 |
kanzure | "Contrary to some assertions by medical professionals, if the human sperm penetrates the hamster egg, a hybrid embryo is indeed created. The resulting hamster-hybrid is known as a humster." | 13:01 |
JayDugger | Not touching that. | 13:03 |
kanzure | "The predictive value of the zona-free hamster egg penetration test in relation to in-vitro fertilization at various insemination concentrations" https://humrep.oxfordjournals.org/content/13/3/624.full.pdf | 13:15 |
kanzure | "Thalamic reticular nucleus induces fast and local modulation of arousal state" https://elifesciences.org/content/4/e08760 | 13:15 |
kanzure | "Here, using optogenetics and whole cortex electrophysiology, we show that local tonic activation of thalamic reticular nucleus (TRN) rapidly induces slow wave activity in a spatially restricted region of cortex. These slow waves resemble those seen in sleep, as cortical units undergo periods of silence phase-locked to the slow wave. Furthermore, animals exhibit behavioural changes consistent ... | 13:15 |
kanzure | ...with a decrease in arousal state during TRN stimulation. We conclude that TRN can induce rapid modulation of local cortical state." | 13:15 |
kanzure | "Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia" http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1917619 | 13:16 |
kanzure | "Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci" http://biorxiv.org/content/early/2016/02/02/031369 PAX8 and VRK2 | 13:44 |
gnusha | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f8eec0ff Bryan Bishop: also TNFα G308A polymorphism for resistance to sleep deprivation >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ | 13:50 |
gnusha | https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=d65be399 Bryan Bishop: also sleep duration >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ | 13:50 |
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kanzure | "I think megabase-scale genome assembly can be evolved in single cells... the easiest path I can see experimentally... definitely will work, question of sequence space and scaffolding... if I think of something better I'll let you know." | 14:28 |
kanzure | "and yeah, like a genome geared toward Gibson assembly... you could get that... select for it too... shoot 1e5 100mers into the right (maybe eukaryotic?) bug... would need to carefully chart the selections and de-selections but I can see it working" | 14:28 |
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kanzure | .tw https://twitter.com/AndrewHires/status/802542688511766528 | 19:05 |
yoleaux | EM Drive thrust effect may be due to thermal expansion? Shouldn't this be on @PubPeer instead of a reddit thread? https://np.reddit.com/r/Physics/comments/5ewj86/so_nasas_em_drive_paper_is_officially_published/dafqhw2/ (@AndrewHires) | 19:05 |
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fenn | the reddit thread boils down to "but look at the curve, it's a classic cooling curve!" when almost half of the paper is spent discussing thermal expansion and how to subtract out the cooling curve | 20:58 |
fenn | i don't understand how that soldered copper foil piece of crap costs $13k to fabricate | 20:59 |
fenn | er, maybe they were talking about a different apparatus | 21:00 |
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fenn | anyway they should have included a cylindrical control | 21:04 |
ybit | there has to be negative consequenceswhen you remove the link between circadian rhythms and sleep. i'll have to read the paper now :) | 21:09 |
fenn | they should be directly comparing on-resonance vs off-resonance curves to determine "thrust" | 21:09 |
fenn | if the power level is the same, the thermal expansion should be the same | 21:10 |
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ybit | ah, or just the quote from kanzure | 21:11 |
fenn | "a cavendish balance approach properly designed to allow very large rotation angles such as 90, 180, or 360 degrees will not be susceptible to this kind of thermal false positive" well then why the fuck didn't you just build that instead | 21:15 |
fenn | ugh this paper is not even wrong | 21:16 |
fenn | .wik john michell | 21:36 |
yoleaux | "John Michell (25 December 1724 - 29 April 1793) was an English clergyman and natural philosopher who provided pioneering insights in a wide range of scientific fields, including astronomy, geology, optics, and gravitation." -- https://en.wikipedia.org/wiki/John_Michell | 21:36 |
fenn | john michell was the actual inventor of "the cavendish balance" | 21:36 |
fenn | a very sensitive torsion pendulum | 21:37 |
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__mz_o | ybit: ive read report regarding circadium rhythms and carcinogenesis | 21:54 |
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__mz_o | ybit: http://www.medscape.com/viewarticle/715702 | 21:59 |
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kanzure | .title | 22:15 |
yoleaux | Medscape: Medscape Access | 22:15 |
kanzure | bleh | 22:15 |
__mz_o | .title http://ar.iiarjournals.org/content/32/7/2747.long | 22:16 |
yoleaux | Role of Melatonin in Cancer Treatment | 22:16 |
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--- Log closed Sun Nov 27 00:00:22 2016 |
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