- A working group outlined a plan for an in-vivo DNA synthesizer that uses four orthogonal polymerases to read unnatural nucleotide “smoke-signals”; the main unsolved bottlenecks are on-demand biosynthesis of the exotic nucleotides and tight genetic-regulatory control.  
- To replace slow diffusion-based signaling, they sketched a coupled-reaction loop in which one enzyme synthesizes DNA from NTPs while another degrades it back to NTPs, creating a clock-like oscillator that could be wired into genetic logic gates.  
- kanzure shared a curated archive of seminal synthetic-biology papers and slide decks—Elowitz repressilator, Weiss & Knight “Towards in-vivo digital circuits,” etc.—to ground the oscillator discussion in existing GRN implementations.  
- A lab sub-project is building an optically driven biological oscillator as a first step toward translating external, frequency-modulated laser signals into transcriptional “Morse code” via phase-locked biological interfaces.  
- The channel debated whether cancer’s suppression of mitochondrial function to evade apoptosis could be countered with synthetic-biology “fail-deadly” replacement cells that bypass DNA-repair failure.  
- Basic open-source biohacker protocols were posted: obtaining pure E. coli, plasmid transformation, single-colony cloning, and workspace sterilization, all framed as steps toward a self-replicating, open-source bioreactor kit.  
- A policy thread on biopunk.org argued that government oversight of biohacking is inevitable; participants compared the coming demonization of underground genetic engineering to the historical stigmatization of computer hackers and linked to the EU SynBioSafe governance forum.  
- Tony (meme.com.au) advised re-branding “the Singularity” for funding purposes, suggesting the more concrete pitch of “breaking the one-brain, one-lifespan limit to the growth of intelligence.”