- BBC Radio 4 programs “Redesigning the Human Body” and “The Human Alien” were shared as background media on human enhancement and transhumanist themes.  
- The channel debated the urgency of replacing “1980s-era biology” with engineered upgrades, framing the body as legacy hardware ripe for modular improvement.  
- kanzure investigated standards for modeling biochemical reaction kinetics, comparing SBML, CellML, BioNetGen (open-source), BioPathwise, and the Yeast Pheromone Model wiki as candidate frameworks.  
- A local mirror of the entire BioModels SBML dataset (release 21 August 2008) was created at /mnt/maxtor/all/Biology/ to support large-scale kinetic modeling.  
- Discussion centered on optimizing genetic-regulatory-network (GRN) parameters—degradation rates, gene-expression rates, polymerase per second (PoPS)—when designing large libraries of BioBrick-based circuits.  
- A plan emerged to couple automated design generation with machine-learning prediction: generate ~10 000 GRN variants, simulate each, and train an artificial neural network (ANN) to predict simulation outcomes from compact design fingerprints.  
- Open questions included how to encode design uniqueness (graph connectivity, parameter sets, permutation IDs, or RNG seeds) as ANN inputs without exploding dimensionality.  
- The cerebellum modeling repository at http://heybryan.org/projects/cerebellum/ (mirrored via git) was noted, though it currently contains mostly Visual Basic code.  
- Object-oriented programming techniques (class extension and inheritance in Python/Java) were discussed as a way to standardize parameter-tweaking interfaces across heterogeneous CAD or SBML models.