- A graph-rewriting pipeline combining GraphSynth, the Fortran SBML simulator hy3s, and PubChem is being prototyped to (1) auto-repair incomplete biological networks, (2) design synthetic genetic circuits from functional specs, and (3) visualize them; Linux build scripts for hy3s are under development.  
- Participants outlined a DIY “Shakti” neural-stimulation rig driven by audio from a PC sound card through simple coils, estimating open-source replication at ~$30 in parts.  
- Japanese artificial-womb work (Kuwabara) was cited as keeping human embryos alive for weeks in vitro, but high disfiguration rates and early termination on humanitarian grounds were noted as current barriers.  
- A web-app architecture was debated for managing an exponentially exploding graph-rewriting search (100 k rules, depth ≥ 6); proposed solutions include per-user RSS feeds of intermediate graphs, asynchronous user voting, and stack-jumping hooks to kill unpopular branches.  
- DIY biology resources shared include an Instructables shot-glass DNA-extraction protocol, low-cost lab hardware discussions, and a wooden-bladed wind-turbine build guide from otherpower.com.  
- Nootropic chemistry discussion covered bulk piracetam (~$35 kg⁻¹), lecithin co-administration to prevent headaches, adrafinil→modafinil conversion, and the lack of solid human data for most life-extension supplements, with links to ImmInst threads and PubMed papers.  
- Fluorinert (perfluorocarbon) was confirmed as a short-term synthetic blood substitute for oxygen delivery, but nutrient transport and pathogen removal remain unsolved; participants lamented the absence of scalable marrow-stem-cell-grown blood.  
- The channel critiqued eugenic selection proposals, arguing that optimizing for survival/reproduction does not guarantee transhuman outcomes and highlighting risks such as reduced genetic diversity and inability to predict future-beneficial genomes.