• DNA origami “lockable boxes” at yoctoliter scale were presented as programmable reactors for in-vitro compartmentalization and directed evolution of small molecules; the 2009 JACS paper describing the system and the open-source SARSE design software (GPL) were shared, and participants explored using AFM tips to stack them into 3-D lattices or microfluidic circuits and employing light-activated azobenzene oligos as addressable keys for selective lid opening.

• A proposal was floated to encode the ~25 most common organic-chemistry reactions as graph-grammar rules in GXML format, with SMILES/SMARTS/SMIRKS and the open-source FROWNS library identified as the canonical toolset for automated reaction simulation; a link to a personal comp-chem resource dump (http://heybryan.org/mediawiki/index.php/Comp_chem_linkdump) and the paper “The potential of a chemical graph transformation system” were circulated.

• A 22 500-run design-of-experiments study on black-and-white film developers was outlined, systematically varying metol, hydroquinone, NaBr, Na₂SO₃, pH (5–14) and temperature to map non-linear synergies and sulfite-scavenging effects, illustrating how open data collection can illuminate complex chemical interactions.

• Retrosynthetic analysis—the Nobel-winning “work-backward” strategy for deconstructing target molecules—was discussed as a potential template for generating build instructions for arbitrary physical artifacts, while frustration was voiced over a published “Route Designer” web tool whose authors described the algorithm but released neither code nor public access.

• NASA’s 630-page “Exploration Systems Architecture Study” (via WikiLeaks) and a $31 M listing for a 640-ft cruise ship were shared as possible blueprints and physical infrastructure for large-scale transhumanist research habitats, alongside practical notes on open-source project management (Graphviz over Gantt charts) and the arrival of new RepRap parts for lab automation.