- A DIYbio-friendly PCB microfluidics service in Florence, Alabama (api-assembled.com) was offered for ultra-low-cost fabrication, though one owner is reportedly hostile to open-inventory requests.  
- The channel compiled a reading list on FR4-based microfluidics, including patents and papers on integrated MEMS single-cell impedance probes and low-cost piezo printheads.  
- Retrosynthetic-analysis tooling was debated: Route Designer’s author demanded a retraction after kanzure labeled it a “black hole,” while kanzure released 1,400-line updates to graphsynth.py to bootstrap a fully open retrosynthesis engine from reaction-mechanism datasets.  
- A 75 MB archive of ~20 000 scraped organic-chemistry reaction mechanisms (PNG) was shared at http://adl.serveftp.org/~bryan/scrapers/mocdb.zip to seed automated route-planning datasets.  
- Participants argued that manually curating ~100 key reaction mechanisms into YAML is sufficient, citing Beilstein’s limited post-1980 journal coverage (80–120 titles) as evidence that exhaustive datasets are unnecessary.  
- Open cheminformatics resources were cataloged—Blue Obelisk blogs, CAOS transform-description language, scraped Methods in Organic Chemistry PDFs—while commercial paywalls like ChemSynth ($599/yr) and Beilstein’s $4k CD were dismissed.  
- Shenzhen’s shanzhai hardware ecosystem (bunniestudios.com, shanzai.com) was praised for rapid open-hardware iteration and sourcing inspiration.  
- Ocean-chemistry data from the U.S. Navy showed ~200× more CO₂ per cubic foot in seawater than in air, raising concerns that acidification may outpace sea-level rise as a global risk.