- The #hplusroadmap channel is framed as a “road-mapping project for transhuman tech,” with an associated wiki and a year-long wait for official Freenode project status.  
- Stanley Knutson’s use of the screen-color-temperature tool f.lux (http://www.stereopsis.com/flux/) for sleep hacking is noted; Linux alternatives discussed include Redshift (http://jonls.dk/redshift/) and xflux.  
- A technical debate explores how to implement sketch-based CAD via Python APIs: participants weigh OpenCASCADE (pythonocc) CSG approaches, UV parameterization for curved surfaces, and the feasibility of importing SVG/DXF versus programmatic 2-D geometry.  
- Open-source CAD pain points are highlighted—BRL-CAD’s CSG limitations, SolidWorks’ size and platform lock-in, and the need for easy shelling/filleting in open tools.  
- DIY-bio links shared: the BioBus “Blue Ribbon” blog post (http://blogs.biobus.org/2010/09/blue-ribbon-biobus/) and Russell Durrett’s open mitochondrial-DNA lab notebook on OpenWetWare (http://openwetware.org/wiki/User:Russell_Durrett/Notebook/mtDNA).  
- Discussion of evolutionary computation and metabiology references Gregory Chaitin’s “Metabiology” essay (http://www.cs.auckland.ac.nz/~chaitin/jack.html) and precedings on scale-free networks (http://precedings.nature.com/documents/4894/version/2).  
- A call for an open “game world” where programs compete via a standardized reality API is floated, inspired by AI Asteroids competitions and Seedea’s simulation index (http://www.innovativ.it/HistoricalArchives/Seedea/Seedea/Simulations).  
- A $21,000 child-sized exoskeleton from Sakakibara-Kikai is critiqued after video review shows it rolls rather than walks (http://www.sakakibara-kikai.co.jp/products/other/ki-w/091222kw-v0.wmv).  
- Fasting-induced autophagy as a longevity mechanism is spotlighted via a Metamodern blog post (http://metamodern.com/2010/07/24/autophagy-why-you-should-eat-yourself).  
- The Life Extension Conference website (http://lifeextensionconference.com) is circulated as an upcoming event of interest.