• A LessWrong draft titled “Open Problems Related to the Singularity” was circulated; it lists three meta-problems: research priorities, the nature of the problem itself, and intervention priorities are all described as “unclear.”

• Discussion of MIT’s “trillion-fps” light-in-motion video clarified that the system is a 1-D slit-camera requiring hundreds of takes, prompting skepticism about whether the resulting data are scientifically meaningful.

• A microscopic Stirling heat engine built from a single microscopic particle was highlighted (Ars Technica article), noted as a step toward MEMS-scale energy harvesting.

• Links to emerging open-science infrastructure were shared: the new biohacking lab at brmlab in Prague (described as “hermetically sealed with duct tape”) and Pumping Station One’s first open-science meetup in Chicago.

• A portable bench-top photolithography tool (Next Big Future post) was flagged as potentially enabling low-cost microfabrication for biohacker spaces.

• Critique of Aubrey de Grey’s “seven strands” longevity roadmap: participants argued the framework is outdated and pointed to a curated longevity-research paper collection (diyhpl.us/~bryan/papers2/longevity/) as a more current resource.

• Questions raised about whether large-scale DNA sequencing is the most direct route to life-extension, with somatic-cell nuclear transfer and stem-cell differentiation cited as nearer-term levers.

• Inquiry into programs that will fund free cancer-genome sequencing for patients, indicating interest in crowdsourced or philanthropic sequencing initiatives.