• A new exercise-induced hormone, irisin (cleaved from the myokine FNDC5), was reported in Nature; it drives white-fat cells toward a brown-fat-like, thermogenic phenotype and improves obesity and glucose homeostasis in mice without altering movement or food intake, suggesting a potential therapeutic route for human metabolic disease.  
• Discussion of incubator economics compared Y Combinator’s current package (~$170 k total: $150 k convertible note + up to $20 k per founder) with JFDI in Singapore (S$15 k for 20 % equity) and a Pennsylvania incubator (≈5 % equity), highlighting regional cost-of-living and equity-dilution trade-offs.  
• A failed Singapore-based startup-weekend team (10 members, “too biz-heavy”) was planning to jettison non-founders and relocate to Bangkok to preserve equity, illustrating common post-weekend team-fracture dynamics.  
• Job-search advice centered on the value of GitHub portfolios versus traditional technical references when applying to “oldschool” employers, with an offer of contract work floated inside the channel.  
• Bottlenose.com’s downtime page was noted for its interactive Asteroids game that lets users shoot page elements while displaying a live score, cited as a clever engagement tactic.