- Alagebrium, an anti-glycation drug that reached Phase II trials, was abandoned for financial reasons yet remains attractive to open-source chemists because synthesis is reportedly straightforward and it once sold on grey markets for ~$3 / g, reopening debate on the ethics of DIY manufacture of compounds with unknown long-term risk but clear short-term benefit for diabetic complications.

- Participants catalogued a broad life-extension pharmacopeia that goes beyond vitamins to include metformin, rasagiline, DMAE, AGE-breakers, C60 in olive oil, low-dose radiation, intermittent fasting, and hormone-replacement therapy, treating these as modular levers for personal experimentation.

- A new forum, bettercryonics.com, was launched to crowd-source scientific improvements in cryonics protocols and already hosts a comprehensive list of cryopreserved individuals, signaling renewed open-source interest in reversible suspended animation.

- The monolithic 3-D chip fabrication patent (ion-cut process) expired in late 2012, potentially removing a major IP barrier to low-cost multilayer semiconductors; links to cost modeling at monolithic3d.com were shared as a starting point for garage-scale 3-D IC projects.

- A deterministic record-replay engine for Linux named Scribe (http://velvetpulse.com/2012/11/27/scribe-the-deterministic-transparent-record-replay-engine/) was highlighted for its ability to log every syscall and later replay a slightly modified binary while tolerating execution divergence, offering a tool for reversible computing and security research.

- A data-driven blog post (http://squid314.livejournal.com/346391.html) synthesizing dozens of studies on prenatal and early-childhood interventions to maximize offspring IQ—including parasite-load reduction, maternal age, and environmental factors—was circulated as a practical guide for transhumanist parenting.

- DIY hardware resources shared included a step-by-step guide for converting a toaster oven into a precision reflow-soldering station (http://viennot.biz/reflow_oven.pdf) and an introductory Verilog tutorial for building a first microprocessor (http://www.gibiansky.com/2012/12/your-very-first-microprocessor.html), underscoring the channel’s commitment to accessible open-source fabrication.

- A heated philosophical debate framed transhumanism as “technological self-improvement and accelerating returns” while distinguishing “conservative” repair (e.g., fixing damaged tissue) from “radical” alteration (e.g., mind-uploading), revealing fault lines within the community over the scope of acceptable human modification.