- Neurotransmitter precursor safety: L-tryptophan and DL-phenylalanine (DLPA) are recommended over 5-HTP because 5-HTP can cause peripheral cardiac damage unless co-administered with carbidopa or EGCG (green-tea catechin) to block peripheral conversion.  
- Ketamine cited as a rapid-acting antidepressant for bipolar depression, with a study showing symptom relief within 40 minutes lasting three days; magnesium proposed as a safer NMDA-antagonist alternative.  
- paperbot, an IRC bot that mirrors pay-walled PDFs from Nature, IEEE, Springer, PLOS, and Science Translational Medicine, was stress-tested; failures revealed gaps in proxy coverage and parsing bugs, particularly with IEEE Xplore and ScienceDirect.  
- A “transhumanist roadmap” discussion identified concrete goals: whole-brain emulation, nootropics delivering orders-of-magnitude cognitive gains (beyond piracetam’s modest effects), longevity research, and non-invasive brain I/O such as transcranial ultrasound.  
- Debate on the value of small IQ boosts (~5 %) concluded that such increments are insufficient for accelerating drug discovery; dedicated research effort, not raw intelligence, is the bottleneck.  
- kanzure’s open-access paper repository at diyhpl.us/~bryan/papers2/ was highlighted as a curated transhumanist literature resource, with participants noting the absence of a dedicated journal and floating the idea of starting one.