• A newly published CRISPR technique that co-opts the bacterial immune system for highly precise DNA editing in human cells was circulated as a landmark advance in open-source gene therapy.  
• Participants dissected the economics of scholarly publishing: Elsevier’s acquisition of the Aureus Sciences drug-discovery database, OCLC’s $0.30-per-API-call pricing, and the absence of first-sale rights for e-books were all cited as evidence that traditional library consortia may collapse within a decade.  
• Paperbot, an IRC bot that serves paywalled PDFs via the open-source Zotero translator library and university proxy credentials, was described in detail; its operator retains perpetual Portland State University access without enrollment, illustrating the grey-market infrastructure sustaining open science.  
• Transcranial focused ultrasound (TUS) for chronic pain was debated: a 2012 human study and newer Neurotrek/Khosla-funded work were criticized for vague outcome measures and the lead author’s controversial quantum-consciousness claims.  
• Cannabinoid pharmacology was explored experimentally; low-CBD, high-THC ratios (<1:20) were reported to enhance concentration and suppress appetite, but with notable individual variability in anxiety response, prompting calls for systematic citizen-science data post-legalization.  
• Reverse-engineering of EZproxy revealed historical buffer overflows and showed how superior UX—not security—won the product market dominance, leading to its 2008 acquisition by OCLC for only $600 k yet continued entrenchment in academic access workflows.  
• Aaron Swartz’s prosecution for bulk-downloading JSTOR was revisited as a flashpoint in the open-access movement, with participants noting that even JSTOR declined civil action while federal prosecutors pursued felony charges.  
• SymbolHound, a search engine that indexes Stack Overflow with exact-symbol support, was praised, but broader frustration was voiced over the lack of byte-level PDF search and the opaque agreements between Google Scholar and major publishers.