- Participants are organizing a Longecity group-buy for ISRIB, an experimental ISR inhibitor that triples LTP in animals, with self-experiments planned despite unknown PTSD-like risks.  
- FourFire proposed an open-source directed-evolution simulator that uses evolutionary algorithms to design synthetic DNA sequences encoding proteins for user-defined tasks such as an intracellular oxygen-storage “ladder” (poly-HexaOxelene) to extend hypoxia survival.  
- A web-based amateur-chemistry tool was sketched that would (1) auto-generate step-by-step synthetic routes for any target molecule, (2) scrape real-time supplier pricing, and (3) graphically depict required reagents and equipment.  
- Consumer-grade BCI options were compared: the upcoming Emotiv Insight headset versus the hacker-oriented OpenBCI dev-board with 3-D-printable mounts, with links to the OpenEEG project and neurofeedback papers (PMC3297423).  
- The channel debated GMO safety, citing cacao swollen-shoot virus (15 % global cocoa loss) as a high-impact target for open, non-patented genetic resistance, and criticized anti-GMO activism for contributing to famine.  
- A consensus emerged that rigorous self-tracking (calories, body mass, reaction times) is essential for any self-experiment, whether for weight loss or cognitive enhancement, with magnesium, GABAergics, and Lion’s Mane (NGF/BDNF up-regulation) mentioned as interventions.