- Open-source hardware development is stifled mainly by lack of shared physical shop space and collaborators; SKDB and an “ontological assimilator” are proposed as meta-tools to let individuals design and build arbitrarily complex hardware without corporate infrastructure.  
- Current open-source CAD is judged inadequate: OpenSCAD’s non-Turing-complete language, STL-only output, and GUI coupling are criticized, while ImplicitCAD and STEP/IGES extensions are discussed as replacements that better support constraint and relationship modeling.  
- A <$500 open-source ultrasound platform is being scoped: $60 single-element Chinese transducers, custom drive electronics, and DIY Schlieren or interferometric calibration in a clear gel tank are proposed to replace $20 k–$50 k clinical machines for both imaging and neuromodulation.  
- Optogenetic cochlear stimulation in mice (J Clin Invest 2014) achieved finer frequency resolution than 16-channel electrical implants; translating this to humans would require a 1-D fiber-optic or micro-mirror array inside the cochlea, raising surgical and packaging challenges.  
- Diet-health evidence shared includes vitamin-D-induced glutathione cutting influenza incidence and the 30–60-year lag between research and public-health recommendations on dietary cholesterol, illustrating systemic friction in personal enhancement.  
- Alibaba and Taobao sourcing is dissected: factories list ultra-low-cost supplies (e.g., $2.50 ft⁻² prefab steel homes, $30 for 14.4 kg bouillon), but MOQs and opaque supplier workflows deter small buyers; channel members offer hand-carry logistics.  
- A proposal to extract human EGF from urine for profit was dismissed after noting research-grade purity requirements and cold-chain logistics inflate costs beyond the apparent $50 µg price tag.  
- The Warburg hypothesis debate re-emerges: mitochondrial dysfunction as a root cause of cancer, the need for tumor-plus-mitochondrial-DNA sequencing, and the possibility of mitochondrial DNA fragments integrating into nuclear DNA.