• A new diyhpluswiki was launched on diyhplus.us to host open-source transhumanist documentation; early commits compare Markdown, YAML, and ikiwiki templates for structuring goals and declarations, with participants noting Markdown’s poor handling of nested lists and limited control.  
• Post-FDA ruling, 23andMe now provides only raw genotype data; users must rely on third-party tools like SNPedia or Promethease for health interpretations, and one participant reported 3.1 % Neanderthal ancestry and sought additional analysis services for VCF/txt files.  
• The U.S. Presidential Bioethics Commission released “Gray Matters,” a report questioning neuroscience research ethics and recommending its own dissolution, fueling debate on equitable access to cognitive enhancement.  
• Participants argued for abolishing or radically reforming the patent system, citing Andrew Torrance’s study “Patents and the Regress of Useful Arts,” and proposed trade secrets as a preferable alternative since reverse engineering can break secrecy while patents legally block knowledge use.  
• Phage-assisted continuous evolution (PACE) was highlighted as a bench-top method for rapidly evolving biomolecules by coupling phage replication to desired enzymatic activities, with discussion of electroporation and heat-shock transfection for DNA delivery.  
• Rational protein-design strategies were shared, including the paper “Beyond directed evolution—semi-rational protein engineering and design,” which details targeted amino-acid substitutions to improve protein tunnels and binding sites, accompanied by animated visualizations of APRT homolog conservation.  
• DIYbio.org’s recent decision to hire a blogger instead of a builder drew criticism, with participants arguing scarce resources should prioritize open-lab hardware over content curation.