- The FDA-cleared SpringTMS device is the first portable single-pulse transcranial magnetic stimulator for migraine, showing a dramatic reduction in size versus conventional rTMS systems and pointing toward consumer-grade neuromodulation hardware.  
- A Cold Spring Harbor Protocols paper on “Miniaturization of Two-Photon Microscopy for Imaging in Freely Moving Animals” was circulated as evidence of open-source progress in wearable, high-resolution brain-imaging hardware.  
- Participants compared light-sheet fluorescence microscopy (LSFM) and two-photon excitation as scalable techniques capable of imaging ~100 000 neurons in a single field of view, underscoring interest in large-scale neural recording.  
- The channel retrieved and shared a 1993 Cell paper and a 2000 Journal of Electron Microscopy article via Paperbot and LibGen, with suggestions to archive the downloads as WARC files to ensure permanent open access.  
- A historical aside highlighted Russian scientist Oleg Losev’s 1920s invention of the LED and a four-electrode silicon-carbide crystal amplifier—an early transistor—decades before Western equivalents, noting his death during the 1942 Leningrad siege.  
- Discussion of modern CPU architectures noted that global clocks vanished after the 80486; today’s chips use multiple asynchronous clock domains with edge-negotiation protocols, complicating single-step hardware debugging.  
- Links shared included a mechanical CPU clock demonstration, Matt Whitlock’s talk on elliptic-curve cryptography as Bitcoin’s foundation, and a 100-year optoelectronics review from the University of Southampton.  
- Participants criticized the idea that open-source hardware must be “not-for-profit,” framed the USPTO’s 14-year backlog on business-method patents as both dysfunction and a potential brake on aggressive patenting, and briefly dismissed MirBSD as an OS “devoted to a ‘wtf’ script and a pdksh clone.”