- Open-hardware true-random generator OneRNG was debated as a fix for Linux /dev/ entropy starvation in servers and VMs, highlighting the risk of reusing random data in virtualized environments.  
- Microfluidics advances were shared via DOIs 10.1039/c4lc00740a, c3lc51360b, c4lc00833b and the MicroTAS 2014 program; a DB-9 connector was noted as a low-cost microfluidic interface.  
- 3-D printing in microgravity was explored through two-photon laser curing of gels for free-floating, ultra-high-resolution structures, with Jordan Miller’s PLOS Biology paper on billion-cell vascular constructs cited as a roadmap for space-based bioprinting.  
- A mouse study (PubMed 24295512) demonstrated a 3-D printed, tooth-shaped biopolymer scaffold seeded with osteoblasts and stem cells that mineralized in vivo and was successfully transplanted into the jaw, illustrating regenerative-medicine progress.  
- Self-replicating lunar/Martian manufacturing was discussed using Freitas 1981 “Growing Lunar Factory,” Toth-Fejel NIAC mechanical replicator concepts, and DNA-origami computational tiling as potential foundations.  
- Two-photon lithography followed by ALD/CVD/sputtering was described for fabricating fractal nanotruss lattices in alumina, nickel, and copper-zirconium, enabling ultra-lightweight mechanical metamaterials.  
- Open-source CAD limitations were compared: FreeCAD (OpenCASCADE) crashes and produces non-manifold geometry, OpenSCAD’s CSG is stable but limited, while commercial kernels like Parasolid remain closed; voxel vs. curved-triangle (AMF) representations were debated for additive manufacturing.  
- Regulatory and DIY-bio hurdles were highlighted: patent-protected biologics (Enbrel, Humira) and controlled substances (HGH) limit replication, while speculative First-Amendment “protein speech” arguments were floated as legal strategy.