- Whole-brain emulation pruning debate: participants argued whether selectively deleting ~400 million “unneeded” neurons could accelerate emulations without destabilizing cognition, and asked what neural circuits could be safely removed.  
- Economic thought experiment: how much debt is rational to incur to fund the creation of additional emulated copies of oneself whose future earnings would repay the loan, referencing Hanson & Miller’s 2012 paper “Economic Implications of Software Minds.”  
- Real-time neuromodulation roadmap: continuous, context-aware control of dopamine/serotonin levels (e.g., high-focus for coding, mild ADD for driving) was proposed, targeting hypothalamic and amygdalar sub-nuclei for stimulation.  
- Open question to neuroscientists: given perfect access to every neuron, where, how, and why would you stimulate to achieve desired cognitive or behavioral outcomes, with implications for both wet-lab experiments and future emulations.  
- Mind-controlled gene expression: a Nature Communications paper was shared describing a wireless, EEG-triggered optogenetic implant that induces transgene expression in vivo, pointing toward closed-loop biofeedback systems.  
- Evolutionary CAD: Autodesk’s “Dreamcatcher” cloud platform autonomously evolves thousands of 3-D design solutions, echoing earlier DIY CAD manifestos and suggesting a path to fully automated hardware design.  
- DIY magnetic flow-meter discussion: practical advice on measuring ionic-liquid flow with Lorentz-force sensors, femtoamp amplifiers, and links to EEVBlog/EDN ultra-low-current design guides.  
- Legacy space-settlement archives: urgent call to back up 1970s-era habitat renderings and technical diagrams from space.mike-combs.com and strout.net/info/science/settlements/ before they disappear.