• A 2015 review paper on DNA methylation in memory formation was shared and discussed, highlighting how methylation acts as a “memory promoter vs. suppressor” balance and suggesting that hippocampal replay may accumulate methylation marks to stabilize long-term memories.  
• Participants debated whether “suppression” in the paper refers to forgetting or merely to the inhibition of synaptic potentiation, noting that one-shot learning could still rely on internal replay loops rather than external repetition.  
• The conversation touched on the stability of double-stranded methylation as a long-term information store and speculated about projection-neuron routing mechanisms that could optimize long-term memory encoding without extensive feedback loops.  
• A conditional knockout mouse line (Prkcztm1a) generated by the International Knockout Mouse Consortium was mentioned as an example of “high-throughput” mammalian genetics, prompting skepticism about the definition of “high-throughput” in academic projects.  
• Links circulated included an anti-patent manifesto (“Culture & Empire”), a libsnark zero-knowledge bug report, a GSM-sniffing tutorial using HackRF, and a wireless mod of a Das Keyboard.  
• DEF CON ticket logistics were noted—cash at the door, no pre-registration—highlighting the conference’s informal, cash-centric culture.