- The community questions the credibility of classic Singularity timelines (Vinge 2005–2030, Kurzweil 2045) and cites a 2014 ESPAS paper arguing for more disciplined long-range technology forecasting methods.  
- A concrete open-science experiment is proposed: evolve non-pathogenic microbes that colonize brain tissue and secrete neurotrophic factors such as BDNF, using magnetic nanoparticles or region-specific targeting to guide secretion; natural precedents like Toxoplasma gondii and Cordyceps are cited as behavioral-manipulation proofs-of-concept.  
- DIY nootropic users recommend bypassing commercial stacks like TruBrain in favor of bulk-sourcing individual compounds (piracetam, noopept, rhodiola, ashwagandha) and capping powders, guided by Examine.com data to control cost, taste, and dosage.  
- Debian’s fully reproducible build initiative (https://wiki.debian.org/ReproducibleBuilds), originally inspired by Bitcoin’s Gitian deterministic builds, is now being adopted Tor-wide as a defense against supply-chain attacks on critical open-source infrastructure.  
- Rust is endorsed as a memory-safe, C-level systems language that retains deterministic performance without Go’s garbage-collection nondeterminism, while Haskell is still preferred for higher-level semantic modeling; MyHDL is rejected because it cannot synthesize to real hardware.  
- Cambrian Genomics’ 2014 interview (http://chemjobber.blogspot.com/2014/11/does-anyone-know-what-cambrian-genomics.html) is critiqued for planning to gate DNA synthesis behind centralized “virtualization labs,” potentially locking down bio-innovation, while their stated 10-year goal of “replacing all natural organisms on the planet with better synthetic ones” is both noted and questioned.