- A new Cell paper reports that long-term memory persistence in the hippocampus is mediated by the prion-like protein CPEB3, whose aggregation after synaptic activity drives local protein synthesis and AMPA-receptor translation; CPEB3 conditional-knockout mice show impaired LTP and spatial memory.  
- Two companion Cell Reports papers add that SUMOylation acts as an inhibitory brake on CPEB3 aggregation and that the CPEB3 prion domain contains a tripartite structure—two aggregation-promoting regions flanking a module that modulates actin-cytoskeleton interaction.  
- Earlier work on NEURL1 (neuralized-like 1) is noted: its overexpression in mice boosts CPEB3 levels, increases synapse number, and enhances memory performance, suggesting a regulatory pathway that could be targeted for cognitive augmentation.  
- Discussion contrasts the new CPEB3 findings with prior emphasis on DNA methylation in neurons, observing that methylation research has focused on memory formation rather than the long-term persistence now linked to prion-like protein aggregation.  
- A 2015 review on DNA methylation in memory formation (linked: diyhpl.us/~bryan/papers2/neuro/DNA%20methylation%20in%20memory%20formation...) is circulated as background reading.  
- Los Angeles Biohackers promote an open 3-D printing meetup with a flyer shared at i.imgur.com/Xr5xdvg.png, illustrating grassroots biohacker engagement with rapid-prototyping tools.