• David Pearce’s “one-file-per-domain” publishing strategy was highlighted: he owns ~10 000 domain names (≈3 700 listed at diyhpl.us/~bryan/irc/david-pearce-domains.url.txt), each hosting a single PDF or HTML page, e.g. biointelligence-explosion.com/biointelligence-explosion.pdf.  
• A parallel Korean example was mentioned—bioinformatician Jong Bhak, who similarly registered thousands of “bio-” prefixed domains (jongbhak.com lists his CV and domain portfolio).  
• Discussion pivoted to practical nanotechnology: the idea of creating modular “protein LEGO” cubes—large protein subunits with switchable linkers that can be chemically enabled/disabled to build arbitrary 3-D nanostructures—was proposed, with concerns about cumulative yield loss over hundreds of assembly steps.  
• Recent literature shared included “Trapping a transition state in a computationally designed protein bottle” (Mills et al., Science 2015) and “Prediction of nucleic acid binding probability in proteins” (Nucleic Acids Res. 2015).  
• Quality-control strategies for DNA/nano synthesizers were debated: whether to embed real-time error-correction (e.g., nanopore QC during synthesis) versus post-synthesis sequencing/mass-spec, weighing parallelism, cost, and step-time trade-offs.  
• Hardware references: Agilent’s inkjet oligo synthesizers achieve >99 % stepwise efficiency; Roche NimbleGen’s discontinued DLP-based maskless microarray systems; photoelectrochemical DNA array synthesis (PMC2741231) with 3 698 pico-reaction chambers.  
• Electrohydrodynamic inkjet printing of multi-material 3-D microstructures (DOI:10.1002/adma.201502092) was circulated, showing sub-micron resolution stacking of functional inks without splashing.  
• CaptHindsight floated integrating DNA repair pathways (base-excision, nucleotide-excision, mismatch repair) directly into synthetic nano-assemblers to auto-correct errors during construction.