• The channel dissected “Physical principles for scalable neural recording” (Marblestone et al.), debating why voltage-reporter contrast agents were left out of Table 1’s modality comparison and what that implies for future scalable brain–computer interfaces.

• Participants proposed speculative biology hacks to make brains easier to record: neurons engineered to spiral axons around electrodes, teratoma-grown bone scaffolds that self-embed probes, and 3-D-printed neural tissue cultured directly on electrode arrays.

• Evidence was cited that fast micro-electrode insertion (<1 mm/day) causes less chronic damage than slow insertion, prompting discussion of optimal implantation speeds and the feasibility of “zero-damage” targets.

• Focused ultrasound plus microparticle delivery through the blood–brain barrier was examined as a route for uniform payload distribution, with interest in receptor-targeted localization to sharpen spatial precision.

• Recent cryonics milestones were shared: successful −45 °C cryopreservation and transplantation of sheep ovaries and rat limbs, and a DoD-funded trial inducing <10 °C hypothermia in trauma patients.

• A 2015 Cell Metabolism paper mapping 4,698 yeast genes whose expression changes under caloric restriction and links the network to extended chronological lifespan was highlighted; participants cautioned that the paper does not explicitly mention “fasting,” suggesting possible over-interpretation in popular discourse.

• Links circulated included an MIT guide to the Servo browser engine, an LSE study showing Wikipedia amplifies the impact of open-access papers, and a Berkeley Nature paper identifying ventral-medulla GABAergic neurons as an on/off switch for REM sleep.