• Selective-breeding mice for reduced sleep must guard against Goodhart’s law: using cortisol alone as a stress proxy risks producing “low-sleep, high-stress, low-cortisol” mutants; multi-marker stress assays (cortisol + intracellular glucocorticoid response + epigenetic readouts + longevity) were proposed to keep the program honest.  
• A radiolabeling proxy for rapid longevity screening—measuring cell-renewal rates—was floated but questioned because extracellular-matrix aging may dominate lifespan more than cell turnover.  
• Continuous, low-volume harvesting of cord blood during pregnancy was suggested as a practical way to bank high-value stem cells without waiting for delivery.  
• Anarchist governance models for an era of ubiquitous bio- and nano-fabrication were debated: “personal archipelago” seasteads/space habitats versus zero-fixed-institution swarms coordinated by personal AIs and AR overlays.  
• MIT OpenAg “Food Computer” open-source controlled-environment agriculture hardware was highlighted as a ready-to-build platform for distributed food-tech experimentation.  
• Wearable-tech wish-list included Twiddler/Chordite chorded keyboards, AR glasses, contact lenses, and jetpacks; participants sought but could not locate a digital Brix refractometer under £50.  
• The 1972 monograph “Ignition!” on liquid rocket propellants was circulated as essential reading for garage-scale propulsion hackers.  
• GDF11 sourcing for anti-aging self-experiments was raised; tongue-in-cheek answer was “dead babies,” with advice to contact known self-experimenters for supply details.