- Cryonics trusts can be structured to sidestep the “rule against perpetuities” by using jurisdictions Alcor has already vetted, and memory-extraction is framed as a worthwhile fallback if full revival fails.  
- OpenAI’s newly announced $1 billion research fund was highlighted as a major new force for open, safety-focused AI development.  
- The MyConnectome project (Nature Communications paper + open data at myconnectome.org) released 18 months of simultaneous fMRI, gene-expression, metabolomic, and behavioral data from one individual to map day-to-day neural variability.  
- Participants proposed patent reforms that would invalidate patents after unchallenged widespread use and dynamically shorten terms each year by the GDP-growth percentage to keep IP aligned with accelerating tech.  
- A speculative Mars-disassembly plan—mining the planet into chunks to eliminate its gravity well—was debated as a way to supply raw material for large-scale space industry.  
- Directed-evolution experiments in mice were outlined for traits such as rapid healing, enhanced cognition, or even cryo-tolerance, with parallel cohorts offsetting long generation times.  
- A microbial nootropic concept: engineer non-pathogenic brain-colonizing microbes to express human neuro-growth factors (e.g., BDNF) and evolve them in maze-tested mice for cognitive enhancement.  
- Practical cryonics consensus: whole-body mammalian freezing is viewed as extremely difficult, while brain-state extraction and uploading is judged “less futile,” though still speculative.  
- A decade-long, high-function amphetamine user without tolerance breaks sparked discussion of individual U-shaped dose–response curves and the limits of generalizing nootropic efficacy.  
- Self-replicating “humongous clanker” machines launched into space could bootstrap planet-scale disassembly within a one-year replication cycle, ultimately enabling Jupiter-brain-scale computation once post-scarcity infrastructure is achieved.