- A neuroanatomy paper praised for mapping non-microcircuit neural pathways is archived at http://diyhpl.us/~bryan/papers2/neuro/cognitiveconsilience/, with kanzure arguing its Google-maps-style visualizations are more useful than traditional “brain regions” taught in psychology.

- OpenWorm’s 2015 review, the DevWorm project, and the ChannelWorm C. elegans ion-channel database are highlighted as open-science resources for whole-organism simulation.

- George Church speculates that head-load-compatible brain expansion (up to 50 kg) and intimate proximity of multiple brains could enable biological “mind-backups” sooner than full computer simulation.

- Participants propose repurposing existing glass-fiber drawing (Corning’s 10 mm → 10 µm shrink) to achieve ~10 nm precision; by slicing fibers into micron sections and assembling them under a microscope, one could bootstrap atomically-precise components without exotic tools, leveraging the 1991 Jansen distortion-control technique and steric-hindrance-based molecular selectivity.

- A review on DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) is shared, showing how engineered GPCRs allow non-invasive, drug-triggered modulation of specific neural circuits in vivo.

- Real-time fMRI neurofeedback is presented as a general method for cognitive enhancement and closed-loop brain training.

- Evidence is cited that the α2A agonist guanfacine (Intuniv) improves planning and spatial working memory in humans, outperforming clonidine, and is linked to anterior cingulate cortex control allocation mechanisms.

- The Expected Value of Control (EVC) theory is summarized: the dorsal anterior cingulate cortex computes the expected value of control to decide how much cognitive effort to invest, integrating payoff, control cost, and effort.

- A study demonstrates a Cre-based double-virus method that retrogradely and locally infects specific projection neurons in macaque prefrontal circuits, enabling pathway-specific optogenetic or chemogenetic manipulation without germline engineering.