- **Mechanical, enzyme-free DNA ligation** is being pursued by attempting to force complementary DNA strands into covalent linkage through controlled mechanical distortion of electron clouds; feasibility is supported by prior demonstrations of mechanochemical bond formation in inorganic systems, and the plan is to test the concept at Lawrence Berkeley Lab’s Molecular Foundry using STMs for real-time imaging.

- **Femtoliter-scale droplet printing** was described as feasible with electrohydrodynamic ink-jet heads and low-wick titanium nozzles, where surface-energy forces dominate over kinetic energy, enabling ultra-precise deposition for microfluidic or synthetic-biology applications.

- **Ultra-long-term data archiving** was debated around the Rosetta Disk (etched-nickel, 7 cm, millennial lifetime) and newer media such as M-Disc’s glassy-carbon layer and the just-announced Q-carbon (claimed harder than diamond and ferromagnetic); participants stressed the need for reproducible data on durability before widespread adoption.

- **A de-novo DNA synthesis business model** was outlined: purchase ~2 kbp oligos from existing vendors, enzymatically stitch them into multi-kilobase constructs, and amplify to high molar yield with high-fidelity polymerase; the global DNA-synthesis market is estimated at ~$2 B and is currently bottlenecked by fidelity limits and maximum commercially viable genome sizes.

- **Open-science infrastructure pain points** included LibGen’s outage prompting discussion of decentralized or commercial mirrors to keep paywalled literature freely accessible, and a reminder that comprehensive graph-transformation databases of chemical reactions remain proprietary despite all bond types ultimately being electron-position phenomena.