- Alcor’s recent cryopreservation of Kim Suozzi is cited as a cautionary case: CT imaging revealed almost no cryoprotectant penetration because hospice transfer delays and a missing night-shift nurse left the patient un-perfused for hours; participants propose that Alcor should run its own “easy-die hospice” to guarantee immediate pronouncement and perfusion.  
- AlphaGo’s 4-1 victory over Lee Sedol sparks debate on whether deep reinforcement-learning plus self-play (millions of games, not billions) constitutes a watershed moment toward AGI, with discussion contrasting human heuristic pattern recognition against neural-network evaluation functions.  
- Channel members push back on claims that MIRI/LessWrong “denied” the significance of AlphaGo, noting that Eliezer Yudkowsky publicly acknowledged it as a major milestone and expressing schadenfreude over earlier LW skepticism of neural nets as “non-Bayesian.”  
- Philosophical discussion questions the definition of “thinking” or “sentience,” suggesting that human cognition itself may rely heavily on internal simulation, making AlphaGo’s approach less alien than commonly assumed.  
- A side observation links cryptocurrency and transhumanist circles, citing Bryan Bishop (mcelrath) and his work on braided blockchains as evidence of ideological overlap.  
- Participants circulate Nature articles on low-cost open-source lab hardware and governance lessons from DIY-bio communities as practical models for decentralizing biotechnology research.