- **Ethical debate on brain emulation**: kanzure argues that even if large-scale virtual torture becomes possible, the same compute capacity could be used for “conservation-of-morality” counter-measures (e.g., endless backups, productive parallel selves) that may outweigh the harms, and that torturers will be out-competed in a resource-costly singularity.

- **Call for massive comparative connectomics**: proposes scanning ≥10,000 mammalian brains across species, factoring out inter-species differences to establish baseline cognitive architectures, and questions why neuroanatomy lags far behind genomics in large-scale data collection.

- **Standardization push for connectomics hardware**: advocates a reusable “cartridge” format for vitrified brain slices that standardizes fluidics, antibody labeling cycles, and physical handling so that machines and protocols are interoperable across labs.

- **Repairing and evolving emulated brains**: suggests using evolutionary or random search on flawed connectome scans to discover nearby designs that function better in simulation, and recommends human-legible graph analysis to spot obvious structural defects.

- **Accelerating neural-tissue selection**: outlines a pipeline to apply directed evolution to organoids or cultured neurons by first selecting for robust in-vitro survival, then for biocompatibility and interface performance, lamenting the slow iteration imposed by mouse-to-culture cycles.

- **DNA-originated aptamer pools for brain labeling**: proposes synthesizing large aptamer arrays against ion channels/receptors, with simultaneous selection for both binding affinity and easy wash-off from vitrified tissue to enable high-resolution antibody-style connectomic labeling.

- **Academic publishing critique**: links to Björn Brembs’ post “Why haven’t we already canceled all subscriptions?” arguing for immediate cancellation of paywalled journal subscriptions.

- **Hardware & wet-lab miscellany**: discussion of metallic glue as a solder replacement, FPGA web-server project, Space Apps Challenge winners, and practical lab questions (micropipette reuse, picotiter plates, inkjet-assisted DNA array washing).