• Forever Healthy Foundation committed $10 M to SENS Research Foundation over five years, specifically funding mitochondrial gene allotopic expression (Dr. Matthew O’Connor), glucosepane cross-link cleavage chemistry (Dr. David Spiegel, Yale), and SENS education programs as part of the broader “Project|21” campaign aiming for $50 M in private rejuvenation-biotech donations.

• Channel members outlined an ambitious “in-vivo DNA polymerase” project whose end-goal is cellular DNA synthesis using only natural amino-acid inputs, eliminating commercial reagents; early prototypes are envisioned as in-vitro nanopore devices.

• Recent US patent applications US20150017655 and US20150065353 describe DNA-sequencing-by-synthesis schemes that read polymerase incorporation electrically via capacitive or conductive labels on the γ-phosphate of each nucleotide analog, using frequency-multiplexed AC signals to distinguish bases without fluorescence.

• Discussion highlighted a suite of related patents on “polymerase enzyme substrates with protein shield” and large (2–50 nm) conductivity labels—metal, semiconductor, polymer, or protein beads—read by nanoFET or impedance sensors, collectively aiming for label-based DNA sequencing and improved phototolerant polymerases.

• Participants debated the evolutionary and thermodynamic limits of DNA polymerase speed, noting that multiple replication forks per cell imply current enzymes are far below theoretical maxima; speculation centered on whether faster, high-fidelity polymerases could be engineered to remove a key bottleneck in synthetic-biology scaling and “grey goo” scenarios.

• A recovered 2008 mailing-list post proposed a “laser-inducible writozyme” concept—an optically controlled enzyme that would synthesize a plasmid in situ and then insert genes—offering an early vision of light-directed enzymatic DNA writing.

• ZnS photocatalysis was presented as a garage-scale route to split water under illumination, with side speculation that the same process could preferentially leave deuterium behind for low-cost D₂O enrichment.

• NIST released open-source code for its STEP file analyzer on GitHub, giving the open biotech hardware community a tool to parse and validate ISO-10303 CAD data for reproducible design workflows.