- DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) were highlighted as a chemogenetic alternative to optogenetics: engineered G-protein-coupled receptors are virally delivered to specific neurons and remotely activated by systemic administration of an otherwise inert ligand (e.g., clozapine-N-oxide), giving long-duration but pharmacokinetically limited control compared with millisecond-precision light stimulation.  
- A 2012 Liu et al. study was cited in which optogenetic re-activation of hippocampal dentate-gyrus neurons tagged during contextual fear conditioning caused mice to freeze in a neutral second context, demonstrating that artificially re-activating an engram can elicit the full behavioral memory.  
- Transcranial infrared laser stimulation (LLLT, 1064 nm, 250 mW cm⁻², 60 J cm⁻² per site) was discussed as a non-invasive cognitive-enhancement method that reportedly improves prefrontal metabolic capacity and memory retention, with a tongue-in-cheek suggestion to control for scalp heating by adding a refrigerator during experiments.  
- The channel reviewed the phenomenon of Highly Superior Autobiographical Memory (HSAM): 11 documented individuals who effortlessly recall vast personal and public event details; structural MRI revealed nine neuroanatomical differences versus controls, offering clues to extreme memory mechanisms.  
- Targeted Memory Reactivation (TMR) during sleep—re-exposing subjects to auditory cues present during prior learning—was noted as a technique to strengthen consolidation without further practice.  
- A Nature Communications paper on “phototriggered protein synthesis” was shared, describing light-activated, caged aminoacyl-tRNAs that enable spatiotemporally controlled translation in living cells.  
- Cell-penetrating peptides (CPPs) were introduced as short sequences that ferry diverse cargos (nanoparticles, DNA, small molecules) across cell membranes, expanding the toolkit for intracellular delivery in biohacking and therapeutic contexts.  
- An ETH Zurich synthetic-biology primer (Part I) was sought; no evidence of Part II was found in the discussion.  
- Market data were posted estimating the molecular-biology enzymes/kits/reagents sector at USD 12.69 billion by 2021, underscoring the economic backdrop for open-source bio-innovation.  
- A new computer-vision beta site (vize.it) was announced for image-tagging services; feedback from the channel urged the developers to pivot away from commoditized vision tasks toward more impactful projects.