- A call was made to create a detailed “AGI roadmap” to guide open-source artificial-general-intelligence development, with at least one participant volunteering to collaborate on the effort.  
- The diyhpluswiki repository was updated with new transcripts and links, including the Scaling Bitcoin Milan “Lightning” session and a timestamping commit that adds OpenTimestamps support.  
- A pre-print claiming “NP vs PSPACE” (arXiv:1609.09562) was circulated, inviting scrutiny from complexity-theory-minded readers in the channel.  
- Robin Hanson’s essay “Could Gambling Save Science?” (mason.gmu.edu/~rhanson/gamble.html) was shared as a provocative proposal for using prediction markets to fund and validate research.  
- PubPeer’s page on “The Heroes of CRISPR” was highlighted, directing attention to post-publication peer review and potential issues in the foundational CRISPR literature.  
- A Princeton working paper on “Privacy-preserving methods for sharing financial risk exposures” (AKL_AER.pdf) was distributed, relevant to both decentralized finance and secure multi-party computation.  
- Extensive discussion of naturally occurring toxins included: psoralen as a potent celery mutagen that rises 8-fold in insect-resistant cultivars; nitrate over-limit findings in lettuce and cress; and evidence that acidic, polluted fog rapidly boosts psoralen levels in plants.  
- News of a major investor lawsuit against Theranos (Hacker News item 12680380) was noted as a cautionary data point for bio-startup culture.  
- President Obama’s NASA op-ed “America Will Take the Giant Leap to Mars” (blogs.nasa.gov/bolden/2016/10/11/makinghumansettlementofspacereality/) was linked, framing Mars settlement as a near-term national goal.