• George Church’s 2014 “Rosetta brains” paper (Marblestone, Church, Boyden) was circulated as a concrete roadmap for molecularly-annotated connectomics that could eventually enable high-resolution brain scanning and reconstruction.  
• A practical nootropics thread produced actionable advice: magnesium citrate/glycinate for anxiety, caution against high-dose PEA for recovering opioid users, and warnings that phenibut is “horribly addictive” while stronger NMDA antagonists (ketamine, DXM) impair working memory.  
• Over-the-counter adrafinil was discussed as a modafinil prodrug, but participants flagged its higher risk of liver toxicity and severe rash compared to prescription modafinil.  
• Memory-enhancement tactics included graduated-interval flash-card systems (Anki) and proposed stacks such as caffeine + piracetam + vinpocetine (cycled every two weeks) and noopept plus a choline source.  
• Technical deep dives covered using Python’s CFFI/ctypes to manipulate AMD64 debug registers for a custom debugger and leveraging Cython for performance-critical Python extensions, with Sage notebook cited as an exemplar of seamless integration.