• A Science paper describes the first directed-evolution of a cytochrome-c enzyme (from Rhodothermus marinus) that catalyzes carbon–silicon bond formation under physiological conditions, achieving >15× higher turnover than the best synthetic catalysts and opening “silicon-to-life” chemistry.  
• Participants warn that over-expressing or “super-charging” a single human enzyme can disrupt metabolic networks, especially for membrane proteins that are hard to model and require in-vitro validation.  
• Bacteria are highlighted as a superior source of enzymes because their short generation times give evolution orders of magnitude more iterations than mammals for any given catalytic task.  
• The diyhpluswiki page http://diyhpl.us/diyhpluswiki/genetic-modifications/ was updated with recent human-gene-editing findings, including the ear-wax variant rs17822931 and the short-sleep DEC2/BHLHE41 mutations.  
• DEC2-P385R and related BHLHE41 variants allow some humans to sleep only 4–5 h per night without cognitive deficits by dampening circadian amplitude; participants speculate on brain-targeted delivery for “sleep-reduction therapy” and note strong funding interest from Asian education markets and military research.  
• Blood-flow-restriction training is presented as a low-damage, evidence-based method (NSCA journal data) to trigger muscle hypertrophy.  
• A WaveNet-based end-to-end English speech-to-text model (GitHub: buriburisuri/speech-to-text-wavenet) is shared as a state-of-the-art neural speech-recognition example.  
• A Reddit visualization of the 50-layer MS-ResNet neural network is circulated to illustrate contemporary deep-learning architectures.