- A new pre-print on “Rapidly evolving homing CRISPR barcodes” (biorxiv 055863) was highlighted; it describes a self-targeting hgRNA/Cas9 cassette that continuously mutates its own DNA sequence at a tunable rate, enabling single-cell lineage tracing, molecular recording and connectome mapping.  
- Discussion of TLSNotary/PageSigner tools for cryptographically proving the contents of HTTPS pages without revealing the full transcript; the current implementation relies on an Amazon AWS-based “oracle,” which participants found architecturally questionable.  
- A participant asked for help computing the electrostatic surface area of the drug codeine; suggested workflows included PDB2PQR + APBS and the alternative finite-element package FEniCS.  
- Metallic hydrogen was noted: a recent arXiv paper reportedly demonstrates formation of the long-sought metallic phase in a diamond-anvil cell under terrestrial pressures.  
- Links to open reading material: the Algorithm Design Manual (PDF), Ted Chiang’s short-story collection (including “Story of Your Life”) recovered via archive.org, and Kevin Kelly’s 2016 book “The Inevitable” were shared and briefly critiqued.  
- Kevin Kelly’s thesis that “we put a phone on everything” was lampooned as overly simplistic transhumanist forecasting.  
- Anecdotal reports on lucid-dream induction hardware (REM Dreamer device ordered from Poland) and Einstein’s elevated glial-cell density were exchanged.