• Cognito Therapeutics is translating Ed Boyden’s Nature paper on 40 Hz gamma entrainment into a non-invasive device that restores gamma oscillations in Alzheimer’s-model mice, triggering microglia to clear β-amyloid plaques and reduce amyloid-β 1-40/1-42 levels, with debate on whether gene-therapy optogenetics or simpler light-flicker protocols can achieve the same effect in humans.

• Channel members compared cryonics (vitrification vs. fixation, carbon-nanotube heat removal, high-pressure gas cooling) with metabolic torpor/hibernation (bear/lemur biochemistry, Mark Roth-style hydrogen-sulfide torpor, Hasan Alam’s Pittsburgh gun-shot-victim trials) as nearer-term routes to biostasis.

• DIY/open-source medical hardware featured an open-source hybrid closed-loop insulin-delivery system built from off-the-shelf parts years before commercial release, alongside The Odin’s expanded CRISPR gene-editing kits and curated 2008-present IRC logs on gene-editing protocols.

• Life-extension discussions highlighted DEC2 and other gene-therapy targets that allow 4–5 h of healthy sleep, Helen Blau’s transient telomerase mRNA lengthening in cultured cells, and the observation that successful adult gene therapies to date are limited to immune-privileged sites such as the eye.

• A new arXiv paper (1610.00293) uses a PDE population model to argue that sleep is evolutionarily inevitable in any temporally variable environment, prompting debate over whether artificial sleep reduction is feasible and citing species (dolphins, fur seals, white-crowned sparrows) that show no sleep rebound after prolonged deprivation.

• Cognitive-enhancement anecdotes suggested Sunifiram up-regulates hippocampal AMPA/NMDA and cholinergic signaling via PKC-α, enabling users to “crystal-clear draw proteins in their head,” while hippocampal damage was linked to loss of vivid mental scene construction.

• Participants debated the scientific validity and ethics of using Nazi hypothermia and rocketry data, criticized bioethicists for ideology-driven obstruction of research, and analyzed how outrage-driven topics (Nazism, identity politics) dominate discourse at the expense of practical transhumanist engineering.