- DNA-Exchange-Imaging (DEI) is introduced as a new method for rapid, highly multiplexed in situ immunofluorescence that replaces slow multi-round staining with a single DNA-barcoded antibody step followed by fast (minute-scale) fluorophore exchange, enabling unlimited spectral multiplexing.  
- The technique is demonstrated on confocal, SIM, STED, and PAINT microscopes, achieving 8-target imaging in ~300 nm resolution in retina sections in 2–3 hours (versus days for prior methods) and 8-target super-resolution imaging at ~20 nm in primary neurons.  
- DEI’s programmable DNA imager strands allow adaptation across sample types (neurons, tumor cells, fresh-frozen or paraffin-embedded tissues) and resolution scales, positioning it for applications in basic science, drug discovery, and clinical pathology.  
- A preprint describing the method is available at http://biorxiv.org/content/early/2017/03/20/112227, and was highlighted by Ed Boyden on Twitter at https://twitter.com/eboyden3/status/844478847290671104.  
- Practical biohacking discussion included sourcing graduated cylinders for 42 mL alcohol measurements, with suggestions to use a kitchen scale or nearby home-brew shops, and a member reporting acquisition of a new laser cutter for the garage workspace.