- A FormLabs Form 1 SLA printer (25 µm resolution) was used to reverse-engineer and 3-D-print a precision thread (0.2 mm radius tolerance, 0.5 mm width) for a high-resolution 3-D reconstruction project; photos at http://imgur.com/a/9svTm.  
- Participants discussed using the resin prints directly in lost-PLA/lost-wax casting to produce metal parts, with an Instructables guide (http://www.instructables.com/id/From-3d-printed-part-to-metal-the-lost-plaabs-me/) cited as evidence the process works.  
- nmz787_i outlined an 8.5-month full-time development plan for a “minimum viable microfluidic DNA synthesizer” intended for personal garage deployment, including dust-isolation retrofits.  
- CNBC reported that synthetic human “mini-genomes” could be implanted in people within five years; the channel linked the article and debated near-term uses of a $10 M Facebook-funded “mutantpedia” project.  
- kanzure proposed non-evil mutantpedia data-collection schemes: genotype users at concert gates, correlate free-form Facebook survey answers with phenotypes, and enlist friends to tag each other’s traits.  
- cluckj countered with “evil” ideas such as mining Facebook data for depression markers and automatically shipping 23andMe kits to affected users.  
- A new CRISPR paper demonstrated in-vivo excision of HIV-1 provirus in live animals using saCas9 and multiple sgRNAs; links to the paper and Hacker News discussion were shared.  
- The DRACO broad-spectrum antiviral project (https://www.ll.mit.edu/news/DRACO.html) was revisited, including its 2015 Indiegogo campaign and ongoing crowdfunding efforts.  
- kanzure posted a full transcript of Gregory Maxwell’s talk on Bitcoin “Confidential Transactions” to http://diyhpl.us/wiki/transcripts/gmaxwell-confidential-transactions/.  
- General skepticism was voiced toward “brain-training” games like dual N-back, with gwern’s meta-analyses dismissed as “evil” after accusations he knowingly published erroneous data.