- **Facebook-scale genomics experiment proposed**: Participants outlined a plan to mine Facebook’s 1.8-billion-user photo and activity corpus to discover genotype–phenotype associations, such as correlating facial skin-aging trajectories with SNP data or using browser zoom settings as a proxy for eyesight quality.

- **Crowdsourced “superpower” phenotypes for GWAS**: Channel members suggested running large surveys asking “What is your friend’s superpower?” to surface heritable traits rarely studied—examples included maintaining unusually large social networks, exceptional vocabulary size, high typing speed, and cognitive sharpness at odd hours.

- **Industrial-scale PCR architecture debate**: Discussion centered on building thermocyclers that can process hundreds of 1-liter reaction bags per run; ideas ranged from dishwasher-style alternating hot/cold water baths to continuous-flow serpentine tubing, with explicit avoidance of slow Peltier elements and known patent minefields.

- **DIY publishing pipeline for non-academics**: Participants explored how independent researchers can publish technical work, covering independent-submission routes, pay-per-page journal models, and the editorial bias favoring institutional affiliations.

- **Key resource links shared**: kanzure posted a longevity paper archive (http://diyhpl.us/~bryan/papers2/longevity/), a George Church transcript (http://diyhpl.us/wiki/transcripts/2017-01-26-george-church/), and a culture-shock repository (https://github.com/kanzure/culture_shock); gnusha_ added transcripts on Mimblewimble and Confidential Transactions.

- **Neuroscience–AI integration literature**: anthk_ and kanzure highlighted the paper “Towards an integration of deep learning and neuroscience” (arXiv:1606.03813) and pointed to ModelDB as a gateway for programmers seeking biologically faithful neuronal simulations in transhumanist research.