• A participant maintains a 5.5 MB YAML plaintext file called “meetlog” that contains every conversation he has had since 2009, entered manually after each interaction; a 2014 Vimeo talk about the project was mentioned but is not publicly indexed.

• Discussion pivoted to the idea that, instead of pursuing error-free oligonucleotide synthesis, the community should engineer biology to tolerate high error rates—specifically seeking proteins that remain functional even when up to 90 % of the DNA sequence contains mistakes.

• Proposed strategies include redesigning the translation machinery for error tolerance, extending codon length beyond the standard three bases, and embedding error-correcting codes directly into codons to allow fuzzy matching and frame-shift recovery.

• A cited experimental paper (http://diyhpl.us/~bryan/papers2/DNA/Error%20analysis%20of%20chemically%20synthesized%20polynucleotides.pdf) was used to ground the conversation in empirical data on phosphoramidite-chemistry error modes, which include skipped bases and other anomalies.

• Practical suggestions emerged, such as appending a fluorescent reporter to detect and select against frameshifted products, followed by post-selection tag removal, while acknowledging that non-coding regulatory regions would also need analogous fault-tolerance mechanisms.