• A user plans to self-experiment with the PPAR-δ agonist GW-501516 (Cardarine) ordered from irc.bio, citing expected endurance and longevity benefits via PGC-1α up-regulation.  
• Extended critique of Zcash: default non-private transactions mislead users, trusted SNARK setup violates “do no harm,” and slow zk-proof generation undermines usability; Monero and Dash are briefly compared but dismissed.  
• Privacy-focused Bitcoin upgrades discussed: Confidential Transactions, Schnorr/BLS signature aggregation, Mimblewimble, TumbleBit (RSA-blinded off-chain hub), and JoinMarket (CoinJoin marketplace); links to papers and transcripts provided.  
• SRF’s two-step “maximally modifiable mice” project described: CRISPR creates a genomic landing pad, then a sequence-specific enzyme inserts genes; tissue-specific insertion efficiency is being evaluated.  
• Proposal to copy whale cancer resistance by adding an extra, fully regulated p53 copy plus longer telomeres, leveraging their large-cell-count longevity.  
• DNA Fountain (NY Genome Center, March 2017) achieves 215 PB/g DNA storage density with perfect retrieval; prior fluorescent exonuclease and light-gated DNA data-storage patents noted.  
• Open question raised: why oligonucleotide synthesis still builds single strands rather than simultaneous double-helix assembly, potentially leveraging modern polymer chemistry for higher yield and lower error.  
• Metformin reviewed as a geroprotector, with warnings about severe gastrointestinal side effects at therapeutic doses.  
• Endogenous erythritol synthesis from glucose via the pentose-phosphate pathway reported in PNAS; speculation it may serve as a microbiome control metabolite analogous to fucose.  
• Discussion of decentralized science tools: Freenet-based data sharing, smart-contract-driven private publication, and Max Ogden’s decentralized research platform; aim to bypass restrictive academic rules.