• A second, independent proof of the CSP Dichotomy Conjecture (arXiv:1704.01914) confirms polynomial-time solvability for every tractable constraint-satisfaction class, but the exponent grows with the class, leaving practical algorithms for future work.

• Thermostable GeoCas9 from Geobacillus stearothermophilus operates at 70 °C, doubles CRISPR target-site diversity through engineered variants, and persists longer in human plasma—advantageous for ribonucleoprotein delivery in vivo (bioRxiv 138867).

• Deskgen released a machine-learning pipeline that automatically designs CRISPR guide RNAs to minimize off-target effects and maximize editing efficiency.

• A cell-penetrating-peptide strategy for nuclear delivery of Cas9 protein was highlighted as a non-viral route to improve in-vivo genome editing (FASEB J abstract 909.4).

• Participants debated an enzymatic error-correction scheme for ultra-low-cost, high-error DNA synthesis that treats oligo pools as error-correcting codes, with discussion of triple redundancy, “majority-vote” enzymatic repair, and speculative recombinase-based iterative decoding.

• Live-streamed garage bio-chat showcased DIY hardware including a newly acquired 3,300 lb focused-ion-beam system intended to micro-fabricate sub-micron spider-silk extrusion dies for producing centimetre-wide, 2 µm-thick silk sheets.

• The conversation noted a plateau in DNA synthesis technology, with current phosphoramidite chemistry stuck near 99 % stepwise efficiency and few credible next-generation chemistries or unnatural-base approaches in sight.

• Ideas for built-in DNA quality control included embedding “NOP” nucleotides around codons to stall polymerase when errors accumulate, and a patented “nicking oligo synthesis” method that uses mismatch-specific endonucleases to degrade faulty strands post-synthesis.

• Participants proposed mining extremophiles such as Deinococcus radiodurans and tardigrades for multi-strand error-correction complexes or novel DNA-repair enzymes that could outperform standard systems.