- A biorxiv pre-print warns that diffusion-MRI tractography produces ~4× more false-positive than true-positive white-matter bundles, undermining the reliability of human connectome studies.  
- IEEE Spectrum reports on the MICrONS program and shows a FISSEQ imaging rig; George Church is quoted saying “it may be much easier to engineer the brain than to understand it,” raising the prospect of task-specific prefrontal-cortex organoids.  
- Channel members debate how to test isolated cortical organoids: kanzure proposes generating thousands of random human cortical organoids, interfacing them with multi-electrode arrays, and screening for trainability on tasks like handwriting recognition or arithmetic.  
- yashgaroth shares insider updates on myostatin-pathway biologics: TIMP2 work is tainted by Alkahest ties, follistatin-Fc fusions express poorly, and Acceleron’s undisclosed ACE-2494 may be a safer ActRIIB variant now entering Phase I.  
- nmz787_i solicits advice on building a low-cost positive-pressure lab (≈20 air changes/h) for IC deprocessing and photolithography, balancing clean-air supply with fume-hood exhaust.  
- rk[ghost] floats the idea of replicating the controversial “DNA teleportation” experiment to settle scientific disputes.  
- Links circulated: NeuroFlight2 paper on cultured neurons flying flight simulators, a rat-brain-robot study, and a Bitcoin protocol walkthrough.