- A CRISPR/Cas9-APEX proximity-labeling method fuses catalytically dead Cas9 to the peroxidase APEX2, enabling one-minute-resolution biotinylation and proteomic mapping of proteins located near any chosen genomic locus in living cells.  
- Three bioRxiv pre-print rebuttals (IDs 153338, 157925, 159707) contend that apparent “unexpected mutations” after in-vivo CRISPR editing are pre-existing variants rather than off-target effects, stressing the necessity of pre- and post-editing sequencing of the same animal.  
- A GWAS of extreme high intelligence (Nature Molecular Psychiatry, 2017) reports three genome-wide significant SNPs in ADAM12 on chromosome 10 and a SNP-based heritability of 0.33—the highest yet for any cognitive trait—though the derived polygenic score explains only 1.6 % of variance in normal-range IQ, prompting debate over the utility of current GWAS frameworks for cognition.  
- Magnetrode probes—micron-scale, room-temperature spin-electronic sensors—have recorded event-related magnetic fields of several nanoteslas inside cat visual cortex, offering a non-optical alternative to optical and electrical neural recording modalities.  
- Microfluidic “fluidic microactuation” devices apply controlled tension to ultra-flexible neural electrodes during implantation, allowing deep-brain insertion without stiffening the probe and providing micron-scale positional control while avoiding intracranial pressure spikes.  
- Oblique light-sheet tomography is highlighted as a fast, high-resolution volumetric imaging technique for intact mouse brains, despite a misleading pre-print date.  
- Participants criticize the biomedical field’s disease-centric focus and call for a “Cambrian explosion” of biological refactoring, speculating on integrating semiconductor-based computation into larger cells to offload regulatory complexity and enable enhancement of positive outliers.  
- The #hplusroadmap channel positions itself as openly defying regulatory bodies (“banned by the Federal Death Administration—5 times”), maintains a searchable log archive at http://gnusha.org/logs, and curates a DIY-bio knowledge wiki at http://diyhpl.us/wiki, reflecting its role as a persistent, open record of transhumanist and biohacking discourse.