• A proposed open-source project aims to shrink the 22 TB Sci-Hub / LibGen corpus by 100–200× through automated detection and removal of PDF bloat—rasterized vector graphics, oversized images, redundant font definitions, and float-coordinate layout data—guided by Lorentz-curve analysis of page-count vs. file-size outliers.

• To ensure quality after aggressive re-compression, participants suggest replacing Sci-Hub CAPTCHAs with crowd-sourced ABX perceptual tests so users unknowingly validate lossy encodings; repeated failures would mark a file as “good enough.”

• Long-term distribution and censorship-resistance strategies include timelock-encrypted releases (with recursive timelocks and Merkle proofs) and a thought experiment of mass-producing ROM-masked chips containing the compressed corpus, later unlocked by a universal decryption key.

• Robin Hanson criticized Cory Doctorow’s novel “Walkaway” for portraying a two-year jump from first human brain emulation to malicious super-AI, arguing that the hardware build-out required for 10,000× simulation speed makes such a timeline implausible.

• A curated reading list on whole-brain emulation was shared, spanning Anders Sandberg’s feasibility study, the 2008 Oxford “Brain Emulation Roadmap,” the 2016 BioSpaun cortical model, and recent connectomic reconstructions of Drosophila and neocortical microcircuits.

• Saitou & Hayashi’s complete in-vitro reconstitution of the mouse female germ line from tail-derived iPS cells—yielding healthy offspring—was highlighted, along with the Polylox barcoding method for tracking hematopoietic stem-cell fates in vivo.

• Near-term applications of iPS-derived gametes include generating cloned human embryos for organ transplantation, with gastruloids (3-D embryonic stem-cell aggregates) proposed as scaffolds for growing transplantable livers or kidneys.

• China’s new “brain-imaging factory” featuring reel-to-reel high-throughput volume electron microscopy was noted as infrastructure that could dramatically accelerate large-scale connectomic mapping projects.